Setembro 2026 - Inventário do mês

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Versão esquemática de Mariana Barosa:

What multimorbidity shows us about guideline-driven evidence based medicine ou Sensible Medicine

TABELA DE CONTÉUDOS:

1. META-REVISÃO

2. REVISÕES SISTEMÁTICAS DE ENSAIOS CONTROLADOS E ALEATORIZADOS (ECAs)

3. ENSAIOS CONTROLADOS E ALEATORIZADOS (ECAs)

4. NORMAS DE ORIENTAÇÃO CLÍNICA

5. OBSERVACIONAIS

   1. Revisões Sistemáticas

   2. Primários

   3. Casos clínicos e séries

6. OPINIÃO

   1. Revisões narrativas

   2. Perspectiva

   3. Notícias

7. FOAMed

Glossário:

✔ ✔ ✔ --> Muito relevante e reforça ou pode mudar a prática

? ? ? --> Muito relevante mas dúvidas

✗ ✗ ✗ --> Não eficaz mas muito relevante (contraria hipóteses e práticas ; valor didáctico ; etc.)

✔ --> Relevante e a favor da prática

? --> Relevante mas dúvidas

✗ --> Não eficaz mas relevante (contraria hipóteses e práticas ; valor didáctico ; etc.)

(sem símbolo) --> Pouco relevante (eventualmente interessante)

(sem símbolo) --> Não eficaz e pouco relevante (eventualmente interessante)

classificação pessoal, nem todos concordarão

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REVISÕES SISTEMÁTICAS de ECAs

tabela de conteúdos ↟

Cardiovascular

✗ ✗ ✗ Long-term efficacy and safety of left atrial appendage closure vs. oral anticoagulation in atrial fibrillation | Europace

Endocrinologia

✔ ✔ ✔ Glucagon-like Peptide-1 Receptor Agonists and Co-agonists for Weight Loss without Diabetes | Annals IntM

Infecciologia, Microbiologia & Antimicrobianos

✔ ✔ ✔ Does Acute Pyelonephritis Skew Outcomes in Registrational Trials of Novel Antibiotics for cUTI? | CID

? ✗ ? Cefepime and Mortality: A Systematic Review and Bayesian Meta-Analysis | JAMA Network Open 

Neurologia

? ? ? IV Thrombolysis Beyond the Conventional Time Window for Acute Ischemic Stroke | JAMA Network Open 

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ENSAIOS CONTROLADOS E ALEATORIZADOS

tabela de conteúdos ↟

Cardiovascular

✔ ? ✔ Safety and efficacy of the 0/1 h pathway for myocardial infarction in the ED — PRESC1SE-MI | Lancet

✔ ? ✔ Discontinuation of statins for primary prevention of ASCVD in 75 years or older — SAGA/SITE | Lancet Healthy L

✔ ? ✔ Anticoagulation for Atrial Fibrillation with Intermediate Stroke Risk — SINGLE-AF | NEJM

✔ ? ✔ Tricuspid-Valve Intervention in Heart Failure — TRIC-I-HF | NEJM

? ? ? Complete Revascularization Guided by Functional Coronary Angiography in STEMI — AIR-STEMI | NEJM

✗ ✗ ✗ Catheter ablation for symptomatic atrial fibrillation — PVI-SHAM-AF | Lancet

✗ ✗ ✗ Cardiovascular Magnetic Resonance to Guide Defibrillator Implantation for LVEF 36-50% - CMR GUIDE | JAMA

✗ ✗ ✗ Targeted Use of Computed Tomographic Coronary Angiography in Acute Chest Pain — TARGET-CTCA | NEJM

✗ ✗ ✗ LDL Cholesterol Lowering w/ Evolocumab Before PCI for Acute Myocardial Infarction — AMUNDSEN | JAMA

Cirurgia, Ortopedia & MFR

✔ Surgery Versus Watchful Waiting for First Metatarsophalangeal Joint Osteoarthritis – HARD | Annals of IntMed

✔ Dapagliflozin and Acute Kidney Injury Following Cardiac Surgery — MERCURI-2 | JAMA

✔ Conventional vs Video-Assisted Laryngoscopy for Perioperative Endotracheal Intubations — COVALENT | JAMA NO

Geral, Geriatria & Paliativos

✗ ✗ ✗ High-Efficiency Particulate Air Filters to Prevent Winter Respiratory Infections in Care Homes - AFRI-c | JAMA IM

Hematologia

✔ All-Trans Retinoic Acid plus Eltrombopag for Refractory/Relapsed Immune Thrombocytopenia | NEJM Evidence

Cold and Room-Temperature Platelets in Cardiac Surgery: The CHIPS Randomized Clinical Trial | JAMA

Infecciologia, Microbiologia & Antimicrobianos

✔ ✔ ✔ Response-Tailored or Standard-Duration Antibiotic Treatment for Infective Endocarditis — POET II | NEJM

✔ ? ✔ Vancomycin Taper and Pulse or Fidaxomicin for Recurrent C. difficile Infection — OpTION | NEJM Evidence

✔ ? ✔ Single-Use vs Reusable Catheters for Intermittent Catheterization in Urinary Retention - COMPARE | JAMA NOp

? ✗ ? Baloxavir, favipiravir, or oseltamivir in non-severe symptomatic seasonal influenza - AD ASTRA | Lancet ID

Neurologia

✗ ✗ ✗ Mechanical Thrombectomy in Ischemic Stroke w/ a Medium or Distal Arterial Occlusion — DISCOUNT | JAMA

✔ Loberamisal for Acute Ischemic Stroke — LAIS | JAMA

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NORMAS DE ORIENTAÇÃO CLÍNICAS - GUIDELINES

tabela de conteúdos ↟

Cardiovascular

Fifth Universal Definition of Myocardial Infarction (2026): On behalf of the Joint ESC/ACC/AHA/WHF Task Fo

2026 ESC Guidelines for the management of heart failure | European Heart Journal

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ESTUDOS OBSERVACIONAIS

PRIMÁRIOS - SUB-ANÁLISE / COORTE / CASO-CONTROLO / INQUÉRITOS / A. ECONÓMICAS

tabela de conteúdos ↟

Cardiovascular

Diagnosis and Management of Patients w/ Suspected Left-Sided Prosthetic Valve Endocarditis According to PET | CID

Diagnóstico e Raciocínio Clínico

Ultrasonography-Guided Core Needle Biopsy in the Diagnostic Pathway of Pelvic Tumors | JAMA Network Open

Gastroenterologia & Hepatologia

✔ A New Paradigm for CDiff: Atypical Presentations Correlating to Acute Gastrointestinal Dysmotility | CID

Geral, Geriatria & Paliativos

Comparative Risk of Hyponatremia Among Patients Treated w/ Second-Generation Antipsychotics | JAMA NetOpen

Hematologia

✔ How High is Too High? The Diagnostic Value of Absolute Eosinophil Count in Excluding Parasitic Infection

Infecciologia, Microbiologia & Antimicrobianos

✔ ✔ ✔ Is C-reactive protein the answer to antibiotics over-prescribing in primary care? A behavioural experiment | JAC

✔ ✔ ✔ Performance and Projected Impact of Synovial Fluid PCR Testing for Patients Evaluated for Septic Arthritis | AIM

Neurologia

Anti-CD320 Autoantibodies and Central Nervous System B12 Deficiency in Idiopathic Myelopathy | JAMA Neurology

Oncologia

✔ ✔ ✔ Patient-reported symptom monitoring in patients with lung cancer — SYMPRO-Lung | Lancet Oncology

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CASOS CLÍNICOS e SÉRIES DE CASOS

tabela de conteúdos ↟

Doente crítico/urgente

Horned-Viper bite: A Clinical Case and Review of Therapeutic Approach | AMP

Gastroenterologia & Hepatologia

Median Arcuate Ligament Syndrome Masked by Cannabis Hyperemesis Syndrome: A Case Report | AIM

Granulomatous Hepatitis Due to Bacillus Calmette-Guérin After the First Intravesical Instillation: A Case Report | AIM

Geral, Geriatria & Paliativos

Unilateral Hearing Loss Leading to a Diagnosis of Neurofibromatosis 2 | AIM 

Imuno-mediadas

A Case of Scleroderma Renal Crisis in a High-Risk Patient | AIM

Infecciologia, Microbiologia & Antimicrobianos

Posterior Circulation Infarctions as Initial Presentation of Giant Cell Arteritis | AIM

Q Fever with Isolated Bone Marrow Involvement | RSPMI

JC Virus Granule Cell Neuronopathy in HIV Patient with Immune Recovery: Case Report | RSPMI

Neurologia

Subacute Combined Degeneration as the Initial Manifestation of Folate Deficiency | AMP

Posterior Circulation Infarctions as Initial Presentation of Giant Cell Arteritis | AIM

Pneumologia

Tracheobronchopathia Osteochondroplastica: A Rare and Unusual Discovery | RSPMI

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OPINIÃO

REVISÃO NÃO-SISTEMÁTICA / NARRATIVA

tabela de conteúdos ↟

Doente crítico/urgente

Acute Porphyria Screening Protocol in the Emergency Department: A Strategy for Early Diagnosis | RSPMI

Management of the Patient with Suspected Sepsis or Septic Shock: Portuguese Prehospital Setting | AMP

Geral, Geriatria & Paliativos

Challenges During the Reproductive Years: State of the Art | RSPMI

POCUS

Point-of-care ultrasound in clinical practice: evidence, outcomes, and challenges | EJIM

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PERSPECTIVA

tabela de conteúdos ↟

Cardiovascular

Reappraising CHAMPION-AF: Does placebo meet noninferiority in stroke prevention? | Heart Rhythm

CHAMPION-AF and CLOSURE-AF: reconciling contrasting results | European Heart Journal

Diagnóstico e Raciocínio Clínico

✔ ✔ ✔ Educating for Doubt: Ethics and Intellectual Honesty | RSPMI

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NOTÍCIAS

tabela de conteúdos ↟

Cardiovascular

Novartis announces Lp(a)HORIZON Phase III topline results for pelacarsen in established cardiovascular disease (CVD)

App Queen of Hearts (ECGs) aprovada pela FDA

CorCal Trial -presented it as a Hot Line in ESC 2026 

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