Outubro 2026 - Inventário do mês

Vide também no Substack

Versão esquemática de Mariana Barosa:

What multimorbidity shows us about guideline-driven evidence based medicine ou Sensible Medicine

TABELA DE CONTÉUDOS:

1. META-REVISÃO

2. REVISÕES SISTEMÁTICAS DE ENSAIOS CONTROLADOS E ALEATORIZADOS (ECAs)

3. ENSAIOS CONTROLADOS E ALEATORIZADOS (ECAs)

4. NORMAS DE ORIENTAÇÃO CLÍNICA

5. OBSERVACIONAIS

   1. Revisões Sistemáticas

   2. Primários

   3. Casos clínicos e séries

6. OPINIÃO

   1. Revisões narrativas

   2. Perspectiva

   3. Notícias

7. FOAMed

Glossário:

✔ ✔ ✔ --> Muito relevante e reforça ou pode mudar a prática

? ? ? --> Muito relevante mas dúvidas

✗ ✗ ✗ --> Não eficaz mas muito relevante (contraria hipóteses e práticas ; valor didáctico ; etc.)

✔ --> Relevante e a favor da prática

? --> Relevante mas dúvidas

✗ --> Não eficaz mas relevante (contraria hipóteses e práticas ; valor didáctico ; etc.)

(sem símbolo) --> Pouco relevante (eventualmente interessante)

(sem símbolo) --> Não eficaz e pouco relevante (eventualmente interessante)

classificação pessoal, nem todos concordarão

---

REVISÕES SISTEMÁTICAS de ECAs

tabela de conteúdos ↟

Cardiovascular

✔ Immediate Versus Staged Complete Revascularization in Multivessel Disease and STEMI | JACC

Infecciologia, Microbiologia & Antimicrobianos

Empiric Antibiotic Therapy for Complicated Urinary Tract Infection | OFID

---

ENSAIOS CONTROLADOS E ALEATORIZADOS

tabela de conteúdos ↟

Cardiovascular

? ? ? Atorvastatin, Cardiovascular Events, and Disability-free Survival in Older Adults — STAREE | NEJM 

? ? ? Catheter-Directed Thrombolysis in Intermediate-High–Risk Pulmonary Embolism — PRAGUE-26 | NEJM

? ? ? Transcatheter Aortic Valve Replacement for LowFlowLowGradient Aortic Valve Stenosis:REBOOT-PARADOX|JACC

? ? ? Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy — ACACIA-HCM | NEJM

? ? ? Evolocumab on Mortality Outcomes in Patients Without Previous Myocardial Infarction or Stroke | Circulation

✗ ✗ ✗ Prehospital Heparin Administration in Patients w/ STEMI Undergoing Primary PCI: HEPARIN-STEMI | Circulation 

Cirurgia, Ortopedia & MFR

? ? ? Intraoperative Dobutamine+Norepinephrine to Prevent Postoperative Acute Kidney Injury in Septic Shock | JAMA 

Robotic vs Thoracolaparoscopic Esophagectomy for Esophageal Cancer — ROBOT-2 | JAMA Surgery

Doente crítico/urgente

✗ ✗ ✗ Effect of Vasopressin Initiation Threshold on Septic Shock Mortality: VASSPR | JAMA

Endocrinologia

✔ ✔ ✔ Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity — TRIUMPH-1 | NEJM

Continuous Glucose Monitoring in Non–Insulin-Treated Type 2 Diabetes — CONNECT | NEJM

Gastroenterologia & Hepatologia

✔ Colonoscopy Intervals and Colorectal Cancer Incidence after Adenoma Removal — EPoS II | NEJM

Geral, Geriatria & Paliativos

✔ ✔ ✔ Communicating Uncertainties About the Benefits and Risks of New Cancer Drugs: Two RCTs | JAMA Int Med

Endometrial ablation plus levonorgestrel-releasing intrauterine system vs endometrial ablation alone - MIRA2 | Lancet

Hematologia

✔ Oral deucrictibant for on-demand treatment of hereditary angioedema attacks — RAPIDe-3 | The Lancet

Imuno-mediadas

✗ ✗ ✗ Rituximab vs Azathioprine for Eosinophilic Granulomatosis w/ Polyangiitis Maintenance Therapy | JAMA

Infecciologia, Microbiologia & Antimicrobianos

✔ ✔ ✔ Short or Long Antibiotic Regimens in Orthopedics — SOLARIO | NEJM

8 weeks vs 12 weeks of sofosbuvir–velpatasvir for treatment-naive, non-cirrhotic, chronic hepatitis C (RESOLVE) | Lancet 

Nefrologia

✔ ✔ ✔ Intermittent or Continuous Renal-Replacement Therapy in Acute Kidney Injury — ICRAKI | NEJM

Neurologia

✔ Remibrutinib vs teriflunomide in relapsing multiple sclerosis (REMODEL-1 and REMODEL-2) | Lancet

✗ ✗ ✗ Tenecteplase Before Thrombectomy at 4.5 to 24 Hours for Basilar Artery Occlusion - ATTENTION LATE | JAMA

---

NORMAS DE ORIENTAÇÃO CLÍNICAS - GUIDELINES

tabela de conteúdos ↟

Geral, Geriatria & Paliativos

Pharmacologic Treatments for Females w/ Menopausal Vasomotor Symptoms: Clinical Guideline From the ACP | AIM

---

ESTUDOS OBSERVACIONAIS

REVISÕES SISTEMÁTICAS COM ESTUDOS OBSERVACIONAIS (com ou sem ECA)

tabela de conteúdos ↟

Psiquiatria

✔ Clinical Evidence on Psilocybin and Its Representation in Media Reporting: A Systematic Review | JAMA Net Open

---

PRIMÁRIOS - SUB-ANÁLISE / COORTE / CASO-CONTROLO / INQUÉRITOS / A. ECONÓMICAS

tabela de conteúdos ↟

IA

✔ ✔ ✔ Conversational Diagnostic Artificial Intelligence in Ambulatory Primary Care: Prospective Feasibility | Lancet

? ? ? Sequential Diagnosis with Language Models | Science

Overuse and False Restraint in LLM Recommendations for Choosing Wisely Scenarios | Annals of Internal Medicine

Imuno-mediadas

✗ Risk of Inflammatory Bowel Disease After Anti-CD20 Treatment in Multiple Sclerosis | JAMA Neurology

Infecciologia, Microbiologia & Antimicrobianos

? ? ? Shorter Antibiotic Duration for Pseudomonas Bacteremia: A Call for Future Trials | AIM

✔ Cephalexin 500 mg 4 Times Daily vs. 1000 mg 3 Times Daily for the Treatment of Uncomplicated Cellulitis | OFID

Performance of the Urinary MycoMEIA Aspergillus Assay as an Aid to Diagnose Invasive Aspergillosis | CID

Neurologia

✔ ✔ ✔ Risk of Inflammatory Bowel Disease After Anti-CD20 Treatment in Multiple Sclerosis | JAMA Neurology

---

CASOS CLÍNICOS e SÉRIES DE CASOS

tabela de conteúdos ↟

Dermatologia

Fluoroquinolone-Induced Bullous Pseudoporphyria in End-Stage Renal Disease | AIM

Doente crítico/urgente

Carbon Monoxide Poisoning: Bilateral Globus Pallidus Lesions as a Key Imaging Clue | RSPMI

Gastroenterologia & Hepatologia

A Rare Case of Idiopathic Adult Giant-Cell Hepatitis | AIM

Neurologia

Olfactory Hallucinations and Acute Psychosis Induced by TMP-SMX: A Case Report and Literature Review | AIM 

POCUS

Caracterização Ultrassonográfica das Ondas ‘To-and-Fro’ com POCUS no Contexto do Serviço de Urgência | AMP

---

OPINIÃO

PERSPECTIVA

tabela de conteúdos ↟

Infecciologia, Microbiologia & Antimicrobianos

✔ ✔ ✔ Oral Fosfomycin for Pyelonephritis: Time for Evidence Over Eminence-based Guidelines | CID

✔ ✔ ✔ Oral Fosfomycin for Complicated Urinary Tract Infection Remains a Murky Issue | CID

✔ When Cultures Fall Silent: What Molecular Diagnostics Are Changing About Pathogen Identification | AIM

---

NOTÍCIAS

tabela de conteúdos ↟

Endocrinologia

Unapproved GLP-1 Drugs Retatrutide and Zenagamtide Sold Online Are No Bargain | JAMA Network Open

FDA Authorizes First Continuous Ketone Monitor for Diabetes | JAMA Network Open

---

✔✔✔ FOAMed

tabela de conteúdos ↟

Geral, Geriatria & Paliativos

What’s the Scoop on Creatine? Effects on strength | TFP

Hematologia

Vitamin B12 Deficiency: Monthly shots or daily pills? | TFP

Imuno-mediadas

CAR-T Reality Check | AIDR

Infecciologia, Microbiologia & Antimicrobianos

Scratching the Surface: What is the most effective treatment for scabies? | TFP08

Does estrogen reduce urinary tract infections (UTIs) in post-menopausal women? | TFP

Should I treat Strep throat? | First10EM

Neurologia

JC: Magnesium for Acute Headache: Maybe, but perhaps not for all..| St. Emlyn's

---

SE QUISERES APOIAR-NOS, SUBSCREVE (...e se te sentires generoso/a, uns trocos ajudam a manter o site...)

👇

PATREON patreon.com/esFOAMeados | SUBSTACK https://esfoameados.substack.com/

Em caso de dúvidas ou sugestões, contacta-nos (e-mail, comentário, substack, twitter, ...). Agradecemos!