Março 2026 - Inventário do mês

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Versão esquemática de Mariana Barosa:

What multimorbidity shows us about guideline-driven evidence based medicine ou Sensible Medicine

TABELA DE CONTÉUDOS:

1. META-REVISÃO

2. REVISÕES SISTEMÁTICAS DE ENSAIOS CONTROLADOS E ALEATORIZADOS (ECAs)

3. ENSAIOS CONTROLADOS E ALEATORIZADOS (ECAs)

4. NORMAS DE ORIENTAÇÃO CLÍNICA

5. OBSERVACIONAIS

   1. Revisões Sistemáticas

   2. Primários

   3. Casos clínicos e séries

6. OPINIÃO

   1. Revisões narrativas

   2. Perspectiva

   3. Notícias

7. FOAMed

Glossário:

✔ ✔ ✔ --> Muito relevante e reforça ou pode mudar a prática

? ? ? --> Muito relevante mas dúvidas

✗ ✗ ✗ --> Não eficaz mas muito relevante (contraria hipóteses e práticas ; valor didáctico ; etc.)

✔ --> Relevante e a favor da prática

? --> Relevante mas dúvidas

✗ --> Não eficaz mas relevante (contraria hipóteses e práticas ; valor didáctico ; etc.)

(sem símbolo) --> Pouco relevante (eventualmente interessante)

(sem símbolo) --> Não eficaz e pouco relevante (eventualmente interessante)

classificação pessoal, nem todos concordarão

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REVISÕES SISTEMÁTICAS de ECAs

tabela de conteúdos ↟

Cardiovascular

✗ ✗ ✗ Fluid restriction in patients with heart failure: a systematic review | Heart 

Endocrinologia

✔ Heterogeneity of Treatment Effects of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss | JAMA Int Med

Geral, Geriatria & Paliativos

✔ Effectiveness of drug interventions to prevent delirium after surgery for older adults: SR & NMA of RCTs | BMJ

Oncologia

✗ ✗ ✗ Hormone therapy use and duration with postoperative radiotherapy for recurrent prostate cancer | Lancet

Psiquiatria

✗ ✗ ✗ Efficacy and safety of cannabinoids for the treatment of mental disorders and substance use disorders|LancetPsy

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ENSAIOS CONTROLADOS E ALEATORIZADOS

tabela de conteúdos ↟

Cardiovascular

✔ ✔ ✔ Bleeding Risk with Apixaban vs. Rivaroxaban in Acute Venous Thromboembolism – COBRRA | NEJM

✗ ✗ ✗ Finerenone in Type 1 Diabetes and Chronic Kidney Disease – FINE-ONE | NEJM

✗ ✗ ✗ Low-Dose Rivaroxaban to Prevent LVentricular Thrombosis After Ant Myocardial Infarction - APERITIF | JAMA C ✗ ✗ ✗ Catheter Ablation and Oral Anticoagulation for Secondary Stroke Prevention in AF - STABLED | JAMA Neuro

Dermatologia

✗ ✗ ✗ Oral ivermectin versus 5% permethrin cream to treat scabies – multicentre cluster RCT | BMJ

Doente crítico/urgente

✗ ✔ ? High-Flow or Standard Oxygen in Acute Hypoxemic Respiratory Failure – SOHO | NEJM

✗ Prehospital Whole Blood in Traumatic Hemorrhage – SWiFT | NEJM

Endocrinologia

✔ Efficacy and safety of once-daily oral orforglipron vs oral semaglutide in type 2 diabetes - ACHIEVE-3 | Lancet

Gastroenterologia & Hepatologia

✔ ? ✔ Initial Vancomycin Taper for the Prevention of Recurrent Clostridioides difficile Infection – TAPER-V | JAMA NetO

Geral, Geriatria & Paliativos

✔ Morphine Plus Acetaminophen for Acute Pain in the Emergency Department - PERCEIVE | JAMA Network Open

? Heart failure therapy in patients with advanced cancer receiving specialized palliative care - EMPATICC | EHJ

? ? ? Holding vs Continuing GLP-1/GIP Agonists Before Upper Endoscopy – OCULUS | JAMA Intern Med

✔ ? ✔ Efficacy and Safety of Obinutuzumab in Active Systemic Lupus Erythematosus – ALLEGORY | NEJM

Oncologia

? ? ? Romiplostim versus Placebo for Chemotherapy-Induced Thrombocytopenia – RECITE | NEJM 

Pneumologia

Medical thoracoscopy with talc poudrage and indwelling pleural catheter insertion (TACTIC) | Lancet Resp Medicine

Psiquiatria

✔ ✔ ✔ Decision-Support System to Antidepressant Treatment in Major Depressive Disorder – PETRUSHKA | JAMA

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ESTUDOS OBSERVACIONAIS

REVISÕES SISTEMÁTICAS COM ESTUDOS OBSERVACIONAIS (com ou sem ECA)

tabela de conteúdos ↟

Endocrinologia

✔ Systematic review and meta-analysis of the treatment of hypernatremia in adult hospitalized patients | JCC

Geral, Geriatria & Paliativos

✔ Guidelines and tools to assess appropriateness of diuretic prescribing and aid deprescribing | Lancet Healthy Long

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PRIMÁRIOS - SUB-ANÁLISE / COORTE / CASO-CONTROLO / INQUÉRITOS / A. ECONÓMICAS

tabela de conteúdos ↟

Geral, Geriatria & Paliativos

✔ Patient Characteristics & Outcomes of Pyelonephritis Treated in Mayo Clinic's Hospital-at-Home Program | OFID

Infecciologia, Microbiologia & Antimicrobianos

✔ Diagnostic Yield of Tongue Swab Compared to Sputum-Based Testing for Tb in Four High-Burden Countries | CID

✗ Estimating changes in MRSA infection rates due to changes in precaution policy | CID

Oncologia

✔✔✔ Older Adults w/ Advanced Cancer Who Prefer Quality of Life vs Prolonging Survival | JAMA Oncology

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CASOS CLÍNICOS e SÉRIES DE CASOS

tabela de conteúdos ↟

Dermatologia

Sequential Drug-Induced DRESS Syndrome With Severe Rhabdomyolysis and Probable Myocarditis | AIM 

Gastroenterologia & Hepatologia

Hyperbaric Oxygen for Refractory Colonic Ulcerations in a Patient With Immunotherapy-Induced Colitis | AIM

Hematologia

Colonic Plasmablastic Lymphoma Exhibiting Unique Endoscopic Phenotypic Changes During UC Therapy | AIM

Imuno-mediadas

When Sarcoidosis Looks Like Myeloma: A Diagnostic Pitfall | AIM

Granulomatosis w/ Polyangiitis Presenting w/ Initially Isolated Cutaneous Facial Ulceration | AIM

Infecciologia, Microbiologia & Antimicrobianos

Beyond Uremia: CKD as a Cryptic Gateway for Opportunistic Neuroinvasion by John Cunningham Virus | AIM

Chronic Q Fever Masquerading as Granulomatous Disease: A Diagnostic Challenge | AIM

Atypical Skull Base Osteomyelitis From Streptococcus parasanguinis | AIM

Cardiac Tamponade Due to Entamoeba histolytica in a Patient in a Nonendemic Region | AIM

Infectious Aortitis Secondary to Gastrointestinal Pathogens: A Case Series and Syndromic Review | AIM

Neurologia

A Case of Dacrystic Seizure in a 72-Year-Old Man | AIM

Pneumologia

Adult Diagnosis of Cystic Fibrosis: A Cause of Recurrent Pneumonia | AIM

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OPINIÃO

REVISÃO NÃO-SISTEMÁTICA / NARRATIVA

tabela de conteúdos ↟

Nefrologia

Evidence-based blood tests for monitoring adults with chronic kidney disease stage G3 in primary care | Lancet PC

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✔✔✔ FOAMed

tabela de conteúdos ↟

Geral, Geriatria & Paliativos

#404 From Nerve Pain to Knee Pain: Gabapentinoids for osteoarthritis | TFP

Imuno-mediadas

Episode 122 – When CRP goes missing | Curious Clinicians

Meta-investigação & MBE

Industry vs Non-Industry Funding for Science | Stop and Think

Oncologia

Critical Appraisal in Breast Cancer: The Essentials in 30 Minutes | The Oncology Shot

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