Maio de 2026 - Inventário do mês

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Versão esquemática de Mariana Barosa:

What multimorbidity shows us about guideline-driven evidence based medicine ou Sensible Medicine

TABELA DE CONTÉUDOS:

1. META-REVISÃO

2. REVISÕES SISTEMÁTICAS DE ENSAIOS CONTROLADOS E ALEATORIZADOS (ECAs)

3. ENSAIOS CONTROLADOS E ALEATORIZADOS (ECAs)

4. NORMAS DE ORIENTAÇÃO CLÍNICA

5. OBSERVACIONAIS

   1. Revisões Sistemáticas

   2. Primários

   3. Casos clínicos e séries

6. OPINIÃO

   1. Revisões narrativas

   2. Perspectiva

   3. Notícias

7. FOAMed

Glossário:

✔ ✔ ✔ --> Muito relevante e reforça ou pode mudar a prática

? ? ? --> Muito relevante mas dúvidas

✗ ✗ ✗ --> Não eficaz mas muito relevante (contraria hipóteses e práticas ; valor didáctico ; etc.)

✔ --> Relevante e a favor da prática

? --> Relevante mas dúvidas

✗ --> Não eficaz mas relevante (contraria hipóteses e práticas ; valor didáctico ; etc.)

(sem símbolo) --> Pouco relevante (eventualmente interessante)

(sem símbolo) --> Não eficaz e pouco relevante (eventualmente interessante)

classificação pessoal, nem todos concordarão

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REVISÕES SISTEMÁTICAS de ECAs

tabela de conteúdos ↟

Cardiovascular

✔ ✔ ✔ Efficacy and Safety of Digitalis Glycosides in Heart Failure: A Meta-Analysis | JAMA

✔ ? ✔ Timing of Complete Revascularization in Patients w/ EAMCESST and Multivessel Disease | Circ Cardiovasc Interv

Doente crítico/urgente

✔ ✔ ✔ Single-Shot Regional Anesthesia for Early Rib Fracture-Associated Pain Management | Acad Emerg Med

Neurologia

✔ ✔ ✔ Effectiveness and Tolerability of Pharmacologic Prophylaxis for Chronic Migraine | Annals of Internal Medicine

✔ ✔ ✔ Endovascular thrombectomy for patients w/ large-core ischaemic stroke presenting up to 24 h - ATLAS | Lancet

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ENSAIOS CONTROLADOS E ALEATORIZADOS

tabela de conteúdos ↟

Cardiovascular

✔ ? ✔ Digoxin in Patients With Symptomatic Rheumatic Heart Disease – Dig-RHD | JAMA

✔ ? ✔ L​ow-dose digoxin in patients w/ heart failure w/ reduced or mildly reduced ejection fraction-DECISION | NatMed

✔ Determining the Physiological Threshold for Angina - ORBITA-FIRE | Circulation ? ? ? Weight Loss in Older Patients With Persistent Atrial Fibrillation - LOSE-AF | JAMA

✗ ? ✗ Pulsed Field Ablation as Initial Therapy for Persistent Atrial Fibrillation – AVANT GUARD | NEJM

Cirurgia, Ortopedia & MFR

? ? ? Chronic Subdural Hematoma With Adjunctive Embolization of Middle Meningeal Artery – EMMA-Can | JAMA

Gastroenterologia & Hepatologia

✔ ✔ ✔ Low-Volume Polyethylene Glycol for Bowel Preparation in Hospitalized Adults - INTERPRET | Annals of IntMed

Geral, Geriatria & Paliativos

? ? ? Twenty-Three–Year Benefits of Sigmoidoscopy Screening for Colorectal Cancer - NORCCAP | AIM

Veteran Affairs’ Whole Health Approach for Chronic Pain Management – wHOPE | JAMA

IA ✔ ✔ ✔ Effects of LLM -generated, patient-oriented discharge summaries on patient activation | Lancet Digital Health

Infecciologia, Microbiologia & Antimicrobianos

✔ ✔ ✔ Three months of weekly rifapentine and isoniazid vs four months of rifampicin for tuberculosis infection | CID

✗ ✗ ✗ Rapid Respiratory Microbiological PoC Testing and Antibiotic Use in Primary Care – RAPID-TEST | JAMA IntMed

Neurologia

- AVC

Antiagregantes plaquetários ? ✗ ? Ticagrelor with aspirin with intravenous thrombolysis in patients with ischaemic stroke in China (TAPIS) | Lancet

Trombólise

? ? ? Adjunctive Intra-Arterial Alteplase After Successful Thrombectomy for Acute Ischemic Stroke – CHOICE-2 | JAMA

✗ ✗ ✗ Intravenous Tenecteplase Prior to Endovascular Treatment for Ischemic Stroke at 4.5 - 24 H – TNK-PLUS | JAMA Trombectomia

? ? ? Endovascular Treatment of Medium-Vessel-Occlusion Strokes – ORIENTAL-MeVO | NEJM

✗ ✗ ✗ Endovascular treatment for medium or distal vessel occlusion stroke (DISTAL): 12-month outcomes|LancetNeuro

Pneumologia

? ✔ ? Phase 3 Trials of Inhaled Treprostinil for Idiopathic Pulmonary Fibrosis – TETON-1+TETON-2 | NEJM

Multicountry assessment of tongue swab for tuberculosis using Xpert MTB/RIF Ultra testing | Lancet Microbe

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NORMAS DE ORIENTAÇÃO CLÍNICAS - GUIDELINES

tabela de conteúdos ↟

Cardiovascular

AVF clinical practice guideline on the care of patients with upper extremity deep venous thrombosis | JVSVLD

Gastroenterologia & Hepatologia

ACG Clinical Guideline: Hepatic Encephalopathy

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ESTUDOS OBSERVACIONAIS

REVISÕES SISTEMÁTICAS COM ESTUDOS OBSERVACIONAIS (com ou sem ECA)

tabela de conteúdos ↟

Cirurgia, Ortopedia & MFR

✔ Worldwide Seasonal Variation in Hospital Admissions for Diverticulitis: A Systematic Review | JAMA Surgery

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PRIMÁRIOS - SUB-ANÁLISE / COORTE / CASO-CONTROLO / INQUÉRITOS / A. ECONÓMICAS

tabela de conteúdos ↟

Cardiovascular

✔ ✔ ✔ Defibrillation current and pad position on ROSC during refractory ventricular fibrillation | Resuscitation

Diagnóstico e Raciocínio Clínico

? ? ? Large Language Model Performance and Clinical Reasoning Tasks | JAMA Network Open

Doente crítico/urgente

✔ ✔ ✔ Safety of Peripheral Vasoactive Drug Administration in Prehospital and Retrieval Medicine (SPOTLESS-2) | AEM

✔ Comparison of 8.4% Sodium Bicarbonate vs 3% SodiumChloride in Severe Hyponatremia:RetrospectiveCohort | AEM

Endocrinologia

✔ Safety of biopsy in phaeochromocytoma/paraganglioma: international, multicentre, retrospective cohort | LancetD&E

Gastroenterologia & Hepatologia

✔ Intestinal ultrasound to detect postoperative recurrence in patients with Crohn's disease | Lancet Gastro & Hepato

Infecciologia, Microbiologia & Antimicrobianos

✗ ✗ ✗ Do C-Reactive Protein Measurements Predict Treatment Failure in Native Vertebral Osteomyelitis? | OFID

✗ 16S rRNA bacterial identification in orthopedic infections and its limited role in antimicrobial stewardship | OFID

Pneumologia

✔ ✔ ✔ Global Initiative for Asthma Updates for Diagnosing Asthma in Adults | JAMA Network Open

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CASOS CLÍNICOS e SÉRIES DE CASOS

tabela de conteúdos ↟

Endocrinologia

Generalized Weakness Due to Hypocalcemia and Hypophosphatemia From Potent Acid Suppression | AIM

Imuno-mediadas

Case of Splenic Marginal Zone Lymphoma Presenting as Acquired Angioedema | AIM

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OPINIÃO

PERSPECTIVA

tabela de conteúdos ↟

Hematologia Evolving challenges in smoldering myeloma trials: shifting endpoint measurement and definitions | JCP

Infecciologia, Microbiologia & Antimicrobianos

✔ Evidence Over Eminence: Rethinking Specialty Guidelines Amid the ATS-IDSA Debate | CID

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NOTÍCIAS

tabela de conteúdos ↟

Cardiovascular

In Remembrance of Eugene Braunwald, the Father of Modern Cardiology | JAMA

Invasive Approach May Not Benefit Frail Older Adults With NSTEMI | JAMA

Infecciologia, Microbiologia & Antimicrobianos

More Than 19 000 Measles Cases in a Month—What the Current Outbreak in Bangladesh Signals to the World | JAMA

Neurologia

FDA Approves New Medication for Agitation Associated With Dementia | JAMA

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✔✔✔ FOAMed

tabela de conteúdos ↟

Cardiovascular

#412 PCSK9 Inhibitors: Cardiovascular prevention panacea or pricey pokes? | TFP

Respondendo Mitos sobre Oclusão Coronária Aguda (OCA) | Medicina baseada em evidências Review of the AFFIRM Trial | Cardiology Trial

Review of the RACE Trial | Cardiology Trial

Severe Hypertriglyceridemia: 5 Pearls Segment | CoreIM

Cirurgia, Ortopedia & MFR Bravery (and Humility) is Needed to do Proper Medical Science | Sensible Medicine

Gastroenterologia & Hepatologia

Hepatorenal Syndrome Part 1: 5 Pearls Segment e Hepatorenal Syndrome Part 2 on Management: 5 Pearls Segment

Geral, Geriatria & Paliativos

#524 SHM Converge 2026–Recap | Curbsiders

#510 Diverticulitis for the Hospitalist | Curbsiders

#512 Sleep Optimization and CBT for Insomnia | Curbsiders Shortening Medical School Will Not Improve Medical Education | Sensible Medicine

Longevity Science - A multi-part series | Sensible Medicine

The Theatre of Treatment | Sensible Medicine

Imuno-mediadas

EBR Journal Club: Ixekizumab + Tirzepatide in Psoriatic Arthritis (TOGETHER-PsA) | AIDDR

The CAR-T Landscape in Autoimmune Disease | AIDDR

Infecciologia, Microbiologia & Antimicrobianos

The News-to-Death Ratio Strikes Again | Trust the evidence

Hantavirus Cruise Ship Update: This is not the next pandemic | Munro Report

Hantavirus, What You Need to Know | Sensible Medicine Not now, Ebola | Munro Report Serial Cycle Thresholds and the Science of Infectiousness | Trust the evidence Oncologia

RASolute 302 (daraxonrasib) in metastatic pancreatic cancer: a revolution? | Oncology Shot

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