Janeiro de 2026 - Inventário do mês

Vide também no Substack

Versão esquemática de Mariana Barosa:

What multimorbidity shows us about guideline-driven evidence based medicine ou Sensible Medicine

TABELA DE CONTÉUDOS:

1. META-REVISÃO

2. REVISÕES SISTEMÁTICAS DE ENSAIOS CONTROLADOS E ALEATORIZADOS (ECAs)

3. ENSAIOS CONTROLADOS E ALEATORIZADOS (ECAs)

4. NORMAS DE ORIENTAÇÃO CLÍNICA

5. OBSERVACIONAIS

   1. Revisões Sistemáticas

   2. Primários

   3. Casos clínicos e séries

6. OPINIÃO

   1. Revisões narrativas

   2. Perspectiva

   3. Notícias

7. FOAMed

Glossário:

✔ ✔ ✔ --> Muito relevante e reforça ou pode mudar a prática

 --> Muito relevante mas dúvidas

✗ ✗ ✗ --> Não eficaz mas muito relevante (contraria hipóteses e práticas ; valor didáctico ; etc.)

✔ --> Relevante e a favor da prática

? --> Relevante mas dúvidas

✗ --> Não eficaz mas relevante (contraria hipóteses e práticas ; valor didáctico ; etc.)

(sem símbolo) --> Pouco relevante (eventualmente interessante)

(sem símbolo) --> Não eficaz e pouco relevante (eventualmente interessante)

classificação pessoal, nem todos concordarão

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META-REVISÃO

Meta-investigação & MBE

✗ ✗ ✗ Impact of Study Hypotheses on Results From RCTs: Standard vs Noninferiority RCTs | Annals of Internal Med

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ENSAIOS CONTROLADOS E ALEATORIZADOS

tabela de conteúdos ↟

Cardiovascular

✔ ✔ ✔ Vernakalant vs procainamide for rapid cardioversion of patients with acute atrial fibrillation (RAFF4) | BMJ

✔ ✔ ✔ Withdrawal of HF therapy after AF rhythm control with ejection fraction normalization - WITHDRAW-AF | EHJ

✔ Pulsed field vs radiofrequency ablation for paroxysmal atrial fibrillation - BEAT PAROX-AF | EHJ

Cirurgia, Ortopedia & MFR

Endoscopic or Open Radial Artery Harvest in Coronary Artery Bypass Surgery — NEO Trial | NEJM Evidence ​

✗ ✗ ✗ Arthroscopic subacromial decompression vs placebo surgery for subacromial pain s., 10y - FIMPACT | BMJ ​

Doente crítico/urgente

✔ ✔ ✔ Femoral nerve block vs IV fentanyl for hip fracture pain in the emergency department | Am J Emerg Med

✔ ? ✔ Ultrasound-Guided Regional Anesthesia by Emergency Physicians for Hip Fractures - EDU–RAPID | JAMA NO

✗ ✗ ✗ Minor Papillotomy for Treatment of Idiopathic Acute Pancreatitis With Pancreas Divisum - SHARP | JAMA

Geral, Geriatria & Paliativos

✔ ✔ ✔ A Lay Health Worker–Led Symptom Intervention and Acute Care Use in Older Adults With Cancer | JAMA

Risk-Based vs Annual Breast Cancer Screening: The WISDOM Randomized Clinical Trial | JAMA

Infecciologia, Microbiologia & Antimicrobianos

✔ ✔ ✔ Comparing Oral vs Parenteral Antimicrobial Therapy (COPAT) Trial | CID

✔ Educational Leaflet about Asymptomatic Bacteriuria / UTI on Antibiotic Preferences Among US Adults ≥65 Y | OFID

✗ Bone biopsy vs ulcer bed biopsy guided antibacterial therapy on remission of diabetic foot osteomyelitis-BeBoP| CID

Meta-investigação & MBE

✔ Inter-rater reliability of CTCAE assessments with or without EORTC patient-reported outcome data | Lancet Oncolog

Neurologia

✔ ✔ ✔ Endovascular vs Medical Treatment of Basilar Artery Occlusion: 3-Year Outcomes of the ATTENTION | JAMA N

Pneumologia

✔ ✔ ✔ Oral Nalbuphine in Idiopathic Pulmonary Fibrosis–Associated Cough – CORAL | JAMA

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NORMAS DE ORIENTAÇÃO CLÍNICAS - GUIDELINES

tabela de conteúdos ↟

Infecciologia, Microbiologia & Antimicrobianos

✔ 2025 Update to WikiGuidelines for the management of pyogenic osteomyelitis in adults | AJM

✔ When and How to Use Subcutaneous Antibiotics | Clinical Infectious Diseases

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ESTUDOS OBSERVACIONAIS

REVISÕES SISTEMÁTICAS COM ESTUDOS OBSERVACIONAIS (com ou sem ECA)

tabela de conteúdos ↟

Endocrinologia

✔ Systematic review and meta-analysis of the treatment of hypernatremia in adult hospitalized patients | JCC

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PRIMÁRIOS - SUB-ANÁLISE / COORTE / CASO-CONTROLO / INQUÉRITOS / A. ECONÓMICAS

tabela de conteúdos ↟

Cardiovascular

✔ ✔ ✔ Blood Pressure Effects and Risk of Hypotension due to IVFurosemide in AcuteDecompensatedHeartFailure|AEM

✔ Switching High-Sensitivity Cardiac Troponin Assays in Suspected ACS | JAMA Cardiology

Cirurgia, Ortopedia & MFR

? ? ? Antibiotic Therapy for Uncomplicated Acute Appendicitis: Ten-Year Follow-Up of the APPAC RCT | JAMA

Doente crítico/urgente

✔ ✔ ✔ Cost-Effectiveness of Pantoprazole to Prevent Upper Gastrointestinal Bleeding in MV – E-REVISE | JAMA NO

✔ ✔ ✔ Age-Adjusted D-Dimer Cutoff Levels to Rule Out Deep Vein Thrombosis | JAMA

✔ Blood biomarkers for the prediction of outcome after cardiac arrest: TTM2 biomarker study | Lancet RespMedicine

Endocrinologia

Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes - CATALYST | Diabetes Care

Geral, Geriatria & Paliativos

✔ ✔ ✔ Claims data to identify adverse events after colonoscopy in a RCT (colorectal cancer screening, Norway) | BMJ O

Infecciologia, Microbiologia & Antimicrobianos

✔ ✔ ✔ Antibiotic use and outcomes in patients hospitalized with CAP and positive respiratory viral assays | CID

✔ ✔ ✔ 2023 ISCVID Duke clinical criteria for infective endocarditis: Impact of excluding fever | Clin Infect Dis

Infectious Diseases Telehealth Outcomes and Opportunities for OPAT From 18 Small Community Hospitals | OFID 

Beyond the 9 to 5: A Cross-sectional Survey of AMStewardship Programs in the US about On-call Models | OFID 

Urologia

Risk Factors and a Prediction Model for Preoperative Concurrent Pathogenic Pyuria in Ureteral Calculi | OFID

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CASOS CLÍNICOS e SÉRIES DE CASOS

tabela de conteúdos ↟

Hematologia

Renal Pelvic and Periureter Masses in Cutaneous and Systemic Plasmacytosis | AIM

Neurologia

Unexplained Headache After Surfing: Diagnosis of a Spinal Cerebrospinal Fluid Leak | AIM

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OPINIÃO

REVISÃO NÃO-SISTEMÁTICA / NARRATIVA

tabela de conteúdos ↟

Meta-investigação & MBE

GRADE Guidance: Update on Developing Good Practice Statements in Guidelines | BMJ-EBM

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PERSPECTIVA

tabela de conteúdos ↟

Geral, Geriatria & Paliativos

✔ ✔ ✔ Things We Do for No Reason: Routinely maintaining IV access in hospitalized patients | Journal of Hospital Med

Infecciologia, Microbiologia & Antimicrobianos

✔ ✔ ✔ We Dissent: Lessons From the 2025 Community-Acquired Pneumonia (CAP) Guidelines | Clin Infectious Dis

✔ ✔ ✔ IDSA Position Statement: Why IDSA Did Not Endorse the CAP Guidelines 2025 Update | Clin Infectious Dis

ALARA in Antimicrobial Stewardship: Adapting Radiation Safety Principles to Address Antibiotic Overuse | CID

POCUS

✔ ✔ ✔ Lung ultrasound for etiological diagnosis of pneumonia in the emergency department - BAL‑LUS | USJ

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✔✔✔ FOAMed

tabela de conteúdos ↟

Cardiovascular

Some Year End Things and A Pro-Tip - Stop and Think

How to Read a Randomized Trial? (The Complete Version) - Cardiology Trials Substack

HiSTORIC Reprise—High-Sensitivity Troponin Here to Stay | Journal Feed

Doente crítico/urgente

STAMP Score Predicts Crashing in Intermediate-High Risk PE - Journal Feed / EJIM

STANDING Algorithm for Vertigo – How Accurate Is It? - Spoon Feed

Risk Factors for ICH in Elderly with Ground-Level Fall _ Journal Feed / AEM

Block Better – How to Make POCUS Nerve Blocks Last Longer - Journal Feed / AEM

How to Do a New Regional Block for Rib Fractures - Journal Feed / Injury

How Many Intubations Before You’re Competent? - Journal Feed / AEM

ANDROMEDA-SHOCK-2 REDUX - Journal Feed

STORM-PE RCT—Thrombectomy for Intermediate-High Risk PE

Block Better – PENG Blocks for Hip Fractures

Hyperkalemia – Can We Use Succinylcholine for RSI?

Gastroenterologia & Hepatologia

Episode 119 – While My Liver Gently Weeps | Curious Clinicians

Geral, Geriatria & Paliativos

#403 A Whiff of Prevention: Treating Male Partners to Reduce Bacterial Vaginosis Recurrence - TFP

Lower GI Bleed Scores – Which Best Predicts Badness? | Journal Feed

Meta-investigação & MBE

The Best Studies of 2025 for Hospital Medicine - Anil Makam, Sensible Medicine

Aging Out of Evidence: Why Cancer Trials Still Miss Older Adults - The oncology shot

Neurologia

What Are the Best LVO Stroke Predictors for EMS? - Journal Feed / AEM

Discharging Delirium Is Dangerous | Journal Feed

Oncologia

The puzzle of PARP inhibitors plus ARPI in Prostate Cancer: 12 mutations, 3 trials, and 5 different labels | Oncology Shot

Pneumologia

#401 Vape Expectations: Are electronic cigarettes the real deal for smoking cessation? (Update) - TFP

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