Hipótese Nula #2 - Oseltamivir, mais insulina, mais ervas chinesas, chat GPT4, HIPÓTESE NULA & etc

2º episódio, aqui vai ele: ÁUDIO | Plataformas habituais

Ficou um pouco maior do que queria, sobretudo porque estava sem o travão dos meus amigos Pedro e Mariana.

Espero que 40 minutos não seja demasiado. Caso seja, acho que o principal é dito nos 1os 20-30minutos.

Até amanhã.

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GLOSSÁRIO

RS de ECAs

Doente crítico/urgente

· Patient-Level Meta-Analysis of Low-Dose Hydrocortisone in Adults with Septic Shock | NEJM Evidence

Infecciologia, Microbiologia & Antimicrobianos

· Evaluation of Oseltamivir Used to Prevent Hospitalization in Outpatients With Influenza | JAMA Internal Medicine

ECAs

Cardiovascular

· Angiotensin-Neprilysin Inhibition in Mildly Reduced or Preserved EF and Worsening Heart Failure | JACC

· Self-administered IN etripamil w/ symptom-prompted, repeat-dose regimen for AVN-dependent SVT - RAPID | Lancet

Doente crítico/urgente

· Video versus Direct Laryngoscopy for Tracheal Intubation of Critically Ill Adults - DEVICE | NEJM

Endocrinologia

· Insulina icodec

o Once-Weekly Insulin Icodec vs Once-Daily Insulin Degludec in Insulin-Naive T2D - ONWARDS 2 | JAMA

o Weekly Icodec versus Daily Glargine U100 in Type 2 Diabetes without Previous Insulin - ONWARDS 1 | NEJM

· Incretinas

o Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity | JAMA Network Open

o Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial | NEJM

Gastroenterologia & Hepatologia

· Randomized placebo-controlled phase 3 trial of vibrating capsule for chronic constipation | Gastroenterology

Geral, Geriatria & Paliativos

· Intervention to Promote Communication About Goals of Care for Hospitalized Patients With Serious Illness | JAMA

Hematologia

· Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia - PACER | NEJM

Infecciologia, Microbiologia & Antimicrobianos

· Continuous vs Intermittent Meropenem Administration in Critically Ill Patients With Sepsis - MERCY | JAMA

Nefrologia

· Effect of Hemodiafiltration or Hemodialysis on Mortality in Kidney Failure - CONVINCE | NEJM

· Balanced crystalloid solution versus saline in deceased donor kidney transplantation - BEST-Fluids | Lancet

Neurologia

· Early versus Later Anticoagulation for Stroke with Atrial Fibrillation - ELAN | NEJM

· Panax notoginseng Saponins in the Treatment of Adults With Ischemic Stroke in China | JAMA Network Open

· Butylphthalide in Patients With Acute Ischemic Stroke - BAST | JAMA Neurology

Neurologia/ORL/Doente urgente

· Semont-Plus or Epley Maneuver in Posterior Canal Benign Paroxysmal Positional Vertigo | JAMA Neurology

--- Normas de Orientação ---

Diagnóstico / Raciocínio Clínico e MCDs

· Joint Advisory Statement: Emergency CT scans and IV Iodinated Contrast | RCEM-RCR

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Revisões Sistemáticas

Doente crítico/urgente

· Observation, aspiration, or tube-thoracostomy for primary spontaneous pneumothorax | Chest

Primários - Sub-análise / Coorte / Caso-controlo / Inquéritos / Análises económicas

Cardiovascular

· P2Y12 Inhibitor Monotherapy / Dual Antiplatelet Therapy After Complex PCI | JACC

· Clinical Outcomes of Intensive Inpatient Blood Pressure Management in Hospitalized Older Adults | JAMA IM

· Bleeding-Related Hospitalizations During Use of Amiodarone With Apixaban or Rivaroxaban in Patients w/ AF | AIM

Diagnóstico & Raciocínio Clínico

· Accuracy of a Generative Artificial Intelligence Model in a Complex Diagnostic Challenge | JAMA Network Open

· Clinically significant contrast-associated AKI after emergent CT angiography of the cerebral arteries | EJIM

Meta-investigação & MBE

· Lack of Treatment Efficacy Derived From Statistically Nonsignificant Results of Randomized Clinical Trials | JAMA

· Prolific non-research authors in high impact scientific journals: meta-research study | Scientometrics

Perspectiva

Geral

· Update in Outpatient General Internal Medicine: Practice-Changing Evidence Published in 2022 | AJM

Meta-investigação & MBE

· Detecting Selection Bias in Observational Studies—When Interventions Work Too Fast | JAMA Internal Medicine

· Promoting Ethical Integrity in Authorship Attribution: Who Can Help More? | Acta Médica Portuguesa

· Catalogue of bias: novelty bias | BMJ-EBM