Fevereiro 2026 - Inventário do mês

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Versão esquemática de Mariana Barosa:

What multimorbidity shows us about guideline-driven evidence based medicine ou Sensible Medicine

TABELA DE CONTÉUDOS:

1. META-REVISÃO

2. REVISÕES SISTEMÁTICAS DE ENSAIOS CONTROLADOS E ALEATORIZADOS (ECAs)

3. ENSAIOS CONTROLADOS E ALEATORIZADOS (ECAs)

4. NORMAS DE ORIENTAÇÃO CLÍNICA

5. OBSERVACIONAIS

   1. Revisões Sistemáticas

   2. Primários

   3. Casos clínicos e séries

6. OPINIÃO

   1. Revisões narrativas

   2. Perspectiva

   3. Notícias

7. FOAMed

Glossário:

✔ ✔ ✔ --> Muito relevante e reforça ou pode mudar a prática

? ? ? --> Muito relevante mas dúvidas

✗ ✗ ✗ --> Não eficaz mas muito relevante (contraria hipóteses e práticas ; valor didáctico ; etc.)

✔ --> Relevante e a favor da prática

? --> Relevante mas dúvidas

✗ --> Não eficaz mas relevante (contraria hipóteses e práticas ; valor didáctico ; etc.)

(sem símbolo) --> Pouco relevante (eventualmente interessante)

(sem símbolo) --> Não eficaz e pouco relevante (eventualmente interessante)

classificação pessoal, nem todos concordarão

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REVISÕES SISTEMÁTICAS de ECAs

tabela de conteúdos ↟

Geral, Geriatria & Paliativos

✔ ✔ ✔ Assessment of adverse effects attributed to statin therapy in product labels – CTT Collaboration | Lancet

✔ Chlorhexidine vs Povidone-Iodine and Incidence of Catheter-Related Infections | JAMA Network Open

Infecciologia, Microbiologia & Antimicrobianos

Antibiotic Prophylaxis Strategies and Surgical Site Infections in Colorectal Surgery | JAMA Network Open

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ENSAIOS CONTROLADOS E ALEATORIZADOS

tabela de conteúdos ↟

Cardiovascular

✔ ✔ ✔ Ticagrelor vs Prasugrel in Patients With Diabetes and Multivessel Coronary Artery Disease - TUXEDO2 | JAMA C

? ✔ ? Pharmacist-led patient-self-testing model for warfarin management in patients MHV replacement | BMJ Open

Cirurgia, Ortopedia & MFR

Provision of knee bracing for knee osteoarthritis (PROP OA) | BMJ

Endocrinologia

✔ ✔ ✔ Fasting vs Nonfasting, Dose-adjusted Levothyroxine Ingestion in Hypothyroidism | J Clin Endocrinol Metab

Efficacy and safety of relacorilant for the treatment of patients with Cushing’s Syndrome - GRACE | Lancet Diab & End

Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients | NEJM Evidence

✗ ✗ ✗ Albumin Replacement Therapy in Septic Shock | JAMA

Geral, Geriatria & Paliativos

? ✔ ? CYP2D6-Guided Opioid Management and Postoperative Pain Control – ADOPT PGx | JAMA Network Open

Electronic Health Record Intervention and Deprescribing for Older Adults - NUDGE‑EHR‑2 | JAMA

3 months vs 12 months of romosozumab for postmenopausal osteoporosis – LIDA | Lancet Diabetes & Endocrinology

Behavioral Activation and Mindfulness Interventions in Older Adults – HEAL-HOA | JAMA Netw Open 

Video Remote Sign Language Interpreting and Health Communication for Deaf Patients | JAMA Netw Open 

Nefrologia

✔ Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring AKI – LIBERATE-D | JAMA

Neurologia

✗ ? ✗ Tenecteplase for Acute Non–Large Vessel Occlusion 4.5 to 24 Hours After Ischemic Stroke – OPTION | JAMA

? ? ? Tenecteplase versus standard medical treatment for basilar artery occlusion within 24 h (TRACE-5) | Lancet

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NORMAS DE ORIENTAÇÃO CLÍNICAS - GUIDELINES

tabela de conteúdos ↟

Nefrologia

✔ KDIGO 2026 Clinical Practice Guideline for the Management of Anemia in Chronic Kidney Disease (CKD) | KDIGO

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ESTUDOS OBSERVACIONAIS

PRIMÁRIOS - SUB-ANÁLISE / COORTE / CASO-CONTROLO / INQUÉRITOS / A. ECONÓMICAS

tabela de conteúdos ↟

Cardiovascular

✔ ✔ ✔ 15-Year Cardiovascular Risk in Patients With Angina Without Obstructive Coronary Arteries | JACC Card Interv 

Gastroenterologia & Hepatologia

✔ ✔ ✔ Long term use of proton pump inhibitors and risk of stomach cancer: population based case-control study | BMJ

Ileocaecal resection vs infliximab for ileal Crohn's disease: retrospective 10-year follow-up, LIR!C | Lancet Gastro & Hep

Geral, Geriatria & Paliativos

✗ ✗ ✗ Incidental Rotator Cuff Abnormalities on Magnetic Resonance Imaging | JAMA Internal Medicine 

Infecciologia, Microbiologia & Antimicrobianos

✔ ✔ ✔ Microbials in Community Pleural Space Infection Using BioFire Joint Infection Panel and Individual PCR | CID

✔ Serum (1,3)-β-D-Glucan and Oral Wash PCR for early detection of Pneumocystis jirovecii pneumonia | OFID 

Psiquiatria

Cost-effectiveness of a transdiagnostic group exercise intervention for mental health in Germany (ImPuls) | Lancet Psy

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CASOS CLÍNICOS e SÉRIES DE CASOS

tabela de conteúdos ↟

Gastroenterologia & Hepatologia

Isolated Cutaneous Perianal Crohn Disease With Rare Perineal Involvement | AIM

Geral, Geriatria & Paliativos

Silica Nephrolithiasis From Commonly Used Over-the-Counter Vitamins and Supplements: A Case Report | AIM

Imuno-mediadas

Isolated Subcutaneous Sarcoidosis (Darier–Roussy Disease) wo/ Systemic Involvement: Challenges | AIM

Neurologia

Unmasking the Diagnosis: A Case of Hemicrania Continua | AIM

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OPINIÃO

REVISÃO NÃO-SISTEMÁTICA / NARRATIVA

tabela de conteúdos ↟

Meta-investigação & MBE

Win Ratio Method for Hierarchical Composite Outcomes in Randomized Clinical Trials | JAMA

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PERSPECTIVA

tabela de conteúdos ↟

Cardiovascular

✔ ✔ ✔ Evidence-Based, Streamlined Approach to Measure Blood Pressure in Primary Care Settings | Hypertension

Geral, Geriatria & Paliativos

FDA Greenlights First Motion Sickness Drug in More Than 40 Years | MedPage Today

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✔✔✔ FOAMed

tabela de conteúdos ↟

Doente crítico/urgente

Quick Hits 65 Occipital Nerve Block, PoCUS in Pulmonary Embolism, Myelopathy, Incidental Neutropenia, ... | EMC

POCUS

Potpourri: Updates & Article Reviews | USGel

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