Junho de 2024 - Inventário do mês

Vide também no Substack

Versão esquemática de Mariana Barosa:

What multimorbidity shows us about guideline-driven evidence based medicine ou Sensible Medicine

TABELA DE CONTÉUDOS:

1. REVISÕES SISTEMÁTICAS DE ENSAIOS CONTROLADOS E ALEATORIZADOS (ECAs)

2. ENSAIOS CONTROLADOS E ALEATORIZADOS (ECAs)

3. NORMAS DE ORIENTAÇÃO CLÍNICA

4. OBSERVACIONAIS

   1. Revisões Sistemáticas

   2. Primários

   3. Casos clínicos e séries

5. OPINIÃO

   1. Revisões narrativas

   2. Perspectiva

   3. Notícias

6. FOAMed

Glossário:

✔✔✔ --> Muito relevante e interessante

✔ --> Relevante e interessante

(sem símbolo) --> Interessante mas pouco relevante

(sem símbolo) --> Pouco relevante e interessante

✗ --> Não relevante e pouco interessante (mas importante por contrariar hipóteses, práticas, ...)

classificação pessoal, nem todos concordarão

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REVISÕES SISTEMÁTICAS de ECAs

tabela de conteúdos ↟

Cardiovascular

Vasodilators for Acute Heart Failure — A Systematic Review with Meta-Analysis | NEJM Evidence

Cirurgia, Ortopedia & MFR

✔ Enhanced Recovery After Surgery (ERAS) Guidelines and Outcomes | JAMA NO

Diagnóstico e Raciocínio Clínico

✔✔✔ Randomised controlled trials evaluating AI in clinical practice: scoping review | Lancet Digital Health

Doente crítico/urgente

??? Proton-Pump Inhibitors to Prevent Gastrointestinal Bleeding — An Updated Meta-Analysis | NEJM Evidence

✗✗✗ A Patient-Level Meta-Analysis of Intensive Glucose Control in Critically Ill Adults | NEJM Evidence

Gastroenterologia & Hepatologia

Extracorporeal Shock-Wave Lithotripsy and Endoscopy for the Treatment of Pain in Chronic Pancreatitis | AIM

Geral, Geriatria & Paliativos

✔✔✔ Ultrasound-guided central venous catheterization around the neck: Systematic review & n-meta-analysis | AJEM

Hematologia

✗✗✗ Patient-Reported Outcomes in Phase 3 Clinical Trials for Blood Cancers | JAMA Network Open

Infecciologia, Microbiologia & Antimicrobianos

??? Prolonged vs Intermittent Infusions of β-Lactam Antibiotics in Adults With Sepsis or Septic Shock | JAMA

Oncologia

✔ Postrecurrence Treatment in Neoadjuvant or Adjuvant FDA Registration Trials | JAMA Oncology

✗ Cardiovascular Events and Androgen Receptor Signaling Inhibitors in Advanced Prostate Cancer | JAMA Oncology

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ENSAIOS CONTROLADOS E ALEATORIZADOS

tabela de conteúdos ↟

Cardiovascular

✔✔✔ Ticagrelor alone vs ticagrelor plus aspirin from 1 to 12 month after PCI in ACS - ULTIMATE-DAPT | Lancet

✔ Intravascular ultrasound-guided vs angiography-guided PCI in acute coronary syndromes - IVUS-ACS | Lancet

✔ Kidney Injury After Minimal Radiographic Contrast Administration in Acute Coronary Syndromes-REMEDIALIV | JACC

✔ Multifaceted Intensive Blood Pressure in Older and Younger Individuals With Hypertension | JAMA Cardiology

Dual vs Single Cardioversion of Atrial Fibrillation in Patients With Obesity | JAMA Cardiology

✗ Transcatheter Aortic Valve Implantation in Low-Risk Tricuspid or Bicuspid Aortic Stenosis - NOTION-2 | EHJ

Cirurgia, Ortopedia & MFR

✔✔✔ Early versus delayed weight-bearing following operatively treated ankle fracture - WAX | Lancet

??? Randomized Trial of Intravenous Amino Acids for Kidney Protection - PROTECTION | NEJM

??? Burr-hole drainage with or without irrigation for chronic subdural haematoma - FINISH | Lancet

✔ Optimal drainage time after evacuation of chronic subdural haematoma - DRAIN TIME 2 | Lancet Neurology

Doente crítico/urgente

✔✔✔ Noninvasive Ventilation for Preoxygenation during Emergency Intubation - PREOXI | NEJM

✔ Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation - REVISE | NEJM

Dapagliflozin for Critically Ill Patients With Acute Organ Dysfunction - DEFENDER | JAMA

Early In-Bed Cycle Ergometry in Mechanically Ventilated Patients | NEJM Evidence

Endocrinologia

✔ Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity - SURMOUNT-OSA | NEJM

Tirzepatide for Weight Reduction in Chinese Adults With Obesity: The SURMOUNT-CN  | JAMA

Phase 3 Trial of Crinecerfont in Adult Congenital Adrenal Hyperplasia - CAHtalyst| NEJM

Jinlida for Diabetes Prevention in Impaired Glucose Tolerance and Multiple Metabolic Abnormalities-FOCUS |JAMA IM

Gastroenterologia & Hepatologia

??? Standard of care versus octreotide in angiodysplasia-related bleeding - OCEAN | Gastroenterology

Geral, Geriatria & Paliativos

✔ Coaches Activating, Reaching, and Engaging Patients to Advance Care Planning - CAREplan | JAMA Oncology

✔ Individualised, progressive walking and education intervention for the prevention of low back pain - WalkBack | Lancet

Stepped Palliative Care for Patients With Advanced Lung Cancer: A Randomized Clinical Trial - STEP PC | JAMA

Collaborative Care for Chronic Pain After Traumatic Brain Injury: A Randomized Clinical Trial | JAMA Network Open

Imuno-mediadas

Efficacy and Safety of Donidalorsen for Hereditary Angioedema - OASIS-HAE | NEJM

Oral Sebetralstat for On-Demand Treatment of Hereditary Angioedema Attacks - KONFIDENT | NEJM

Infecciologia, Microbiologia & Antimicrobianos

??? Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis - The BLING III  | JAMA

✗✗✗ Nirmatrelvir-Ritonavir and Symptoms in Adults With Postacute Sequelae of SARS-CoV-2 Infection - STOP-PASC

✔ Mailed feedback to primary care physicians on antibiotic prescribing for patients aged 65 years and older | BMJ

Peceleganan Spray for the Treatment of Skin Wound Infections: A Randomized Clinical Trial | JAMA Network Open

Neurologia

Tenecteplase for Ischemic Stroke at 4.5 to 24 Hours without Thrombectomy - TRACE-III | NEJM

Reteplase versus Alteplase for Acute Ischemic Stroke - RAISE | NEJM

Tenecteplase vs alteplase in perfusion imaging within 4·5 h of onset of ischaemic stroke - TASTE | Lancet Neurology

Long-term colchicine for the prevention of vascular recurrent events in non-cardioembolic stroke - CONVINCE | Lancet

Oftalmologia

Stereotactic radiotherapy for neovascular age-related macular degeneration - STAR | Lancet

Oncologia

Doublet, triplet, or doublet ChemoT w/ RT as NeoAdj locally advanced oesophageal cancer - JCOG1109 NExT | Lancet

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NORMAS DE ORIENTAÇÃO CLÍNICAS - GUIDELINES

tabela de conteúdos ↟

Inteligência Artificial

Artificial Intelligence in the Provision of Health Care: An American College of Physicians Policy Position Paper | AIM

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ESTUDOS OBSERVACIONAIS

REVISÕES SISTEMÁTICAS COM ESTUDOS OBSERVACIONAIS (com ou sem ECA)

tabela de conteúdos ↟

Cardiovascular

✗ Anticoagulation for post-operative atrial fibrillation after isolated coronary artery bypass grafting | EHJ

Gastroenterologia & Hepatologia

✔ Severe Acute Liver Injury After Hepatotoxic Medication Initiation in Real-World Data | JAMA Internal Medicine

Infecciologia, Microbiologia & Antimicrobianos

✔ PCR on Respiratory Tract Specimens of Immunocompromised Patients to Diagnose Pneumocystis Pneumonia | CID

Association between Mycoplasma genitalium and Pelvic inflammatory disease (PID) | Open Forum of Infectious Disease

Nefrologia

✔✔✔ SGLT2i and the risk for dialysis and cardiovascular disease in patients with stage 5 chronic kidney disease | AIM

Kidney Function Biomarkers During Extreme Heat Exposure in Young and Older Adults | JAMA

Oncologia

✔✔✔ Red Flag Signs and Symptoms for Patients With Early-Onset Colorectal Cancer | JAMA Network Open

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PRIMÁRIOS - SUB-ANÁLISE / COORTE / CASO-CONTROLO / INQUÉRITOS / A. ECONÓMICAS

tabela de conteúdos ↟

Cardiovascular

✔ Mineralocorticoid Receptor Antagonists in Patients With Heart Failure and Impaired Renal Function | JACC

✗ Cannabis for chronic pain: cardiovascular safety in a nationwide Danish study | EHJ

Transcatheter or Surgical Replacement for Failed Bioprosthetic Aortic Valves | JAMA Cardiology

Cirurgia, Ortopedia & MFR

✔✔✔ Cost-effectiveness of craniotomy vs decompressive craniectomy for traumatic acute subdural haematoma | BMJ Open

Antiplatelet therapy after coronary artery bypass surgery: five year follow-up of randomised DACAB trial | BMJ

✗ Periprosthetic Joint Infection After Total Knee Arthroplasty With or Without Antibiotic Bone Cement | JAMA NO

Doente crítico/urgente

✔ Emergency Medical Service Agency Practices and Cardiac Arrest Survival - CARES cohort | JAMA Cardiology

Gastroenterologia & Hepatologia

✗ High-dose proton pump inhibitor treatment is associated with a higher mortality in cirrhotic patients | APT

Geral, Geriatria & Paliativos

Association of ultra-processed food consumption with all cause and cause specific mortality | AMP

Hematologia

✔ Neutropenic sepsis in the ICU: differences in clinical profile and outcomes according to neutropenia | OFID

Thrombotic risk and features of patients with inferior vena cava agenesis | Lancet Haematology

Imuno-mediadas

✔ Axial spondyloarthritis in patients with chronic back pain of less than 2 years duration - SPACE cohort | ARD

✔ Sodium-Glucose Cotransporter-2 Inhibitors and Nephritis Among Systemic Lupus Erythematosus | JAMA NO

✗ Limited diagnostic and prognostic value of routine radiographs in newly presenting arthritis suspected of RA | ACR

Infecciologia, Microbiologia & Antimicrobianos

✔ Characteristics and Outcome of Vascular Graft Infections - A Risk Factor and Survival Analysis | OFID

✔ North American ID specialists regarding oral and suppressive antibiotics for adult OA infections - EIN survey | OFID

✔ Antimicrobial Resistance Patterns of Outpatient Staphylococcus aureus Isolates | JAMA Network Open

Mortality and End-of-Life Care Associated with Infectious Disease Consultation in an Academic Health System | CID

HANDOC score for the diagnosis of infective endocarditis among patients with streptococcal bacteremia | CID

Bloodstream Infections Due to Enterococcal Species Other Than Enterococcus faecalis or E. faecium In Cancer | OFID

Recommendations for Updating Fever and Inflammation of Unknown Origin - Modified Delphi Consensus Panel | OFID

Meta-investigação & MBE

✔✔✔ Vibration of effects resulting from treatment selection in mixed-treatment comparisons | BMJ-EBM

✗ Epidemic outcome following government response to COVID19: Nearly 100.000 models | ScienceAdvances

Neurologia

✔ Angiotensin Receptor Blockers for Hypertension and Risk of Epilepsy | JAMA Neurology

✔ Endovascular treatment of acute ischaemic stroke in the late window - MR CLEAN-LATE | Lancet Neurology

Oncologia

✔ Patient Safety and Satisfaction With Fully Remote Management of Radiation Oncology Care | JAMA Network Open

✗ ESMO Magnitude of Clinical Benefit Scale to assess the clinical benefit of antibody drug conjugates | BMJ Open

Psiquiatria

✔ Cognitive Impairments in 1st-Episode Negative Symptom–Dominant Psychosis | JAMA Network Open

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CASOS CLÍNICOS e SÉRIES DE CASOS

tabela de conteúdos ↟

Cardiovascular

Enfarte Agudo de Miocárdio Inferior: Além da Elevação do Segmento ST - RSPMI

Doente crítico/urgente

Intoxicação Aguda por Ferro: Um Caso de Falência Hepática Fulminante | AMP

Endocrinologia

Euglycemic Ketoacidosis After the Addition of Glucagon-Like Peptide-1 Receptor Agonist: A Case Report | AIM

Síndrome de Marine-Lenhart: Uma Perspetiva Clínica e Diagnóstico, a Propósito de um Caso Clínico | RSPMI

Gastroenterologia & Hepatologia

Hemolytic Anemia in Cirrhosis: A Case of Spur-Cell Anemia | AIM 

Geral, Geriatria & Paliativos

Neuroestimulador Medular no Tratamento da Nevralgia Pós-Herpética Refratária em Portugal: Um Caso Clínico | AMP

Imuno-mediadas

Chronic Myelomonocytic Leukemia Associated With TAFRO Syndrome-Like Symptoms | AIM

Infecciologia, Microbiologia & Antimicrobianos

Thumbprint Abdominal Retiform Purpura: Immediate Recognition of Disseminated Strongyloidiasis | AIM

Nefrologia

Diffuse Podocytopathy Associated With Semaglutide | AIM

Neurologia

Diabetic Striatopathy: A Rare Case Report of Chorea, Hyperglycemia, Basal Ganglia (C-H-BG) Syndrome | AIM

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OPINIÃO

REVISÃO NÃO-SISTEMÁTICA / NARRATIVA

tabela de conteúdos ↟

Inteligência Artificial

Aplicação de Inteligência Artificial em Cuidados de Saúde: Mais Inteligência Artificial que Seja Interpretável | AMP

Infecciologia, Microbiologia & Antimicrobianos

✔ The use of long-term antibiotics for suppression of bacterial infections | CID

Meta-investigação & MBE

Lifting the veil off treatment effect heterogeneity | American Heart Journal

POCUS

Point-of-care ultrasound in infectious diseases: Current insights and future perspectives | CID

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PERSPECTIVA

tabela de conteúdos ↟

Cirurgia, Ortopedia & MFR

Corticosteroid Injections and Risk of Fracture | JAMA Network Open

Geral, Geriatria & Paliativos

Pregabalin: How long will we allow this to continue? | Trust the evidence / BMJ Open

Hematologia

Anticoagulating people forever after unprovoked VTE lacks robust evidence | Sensible Medicine

Imuno-mediadas

Infecciologia, Microbiologia & Antimicrobianos

Therapeutic Myths in Solid Organ Transplantation Infectious Diseases | PFID

Meta-investigação & MBE

Correspondence with a Reporter Regarding Industry Payments to US Physicians | Andrew Foy Substack

A Companion to Understanding Regulatory Data | Trust the Evidence

Observational studies of COVID vaccine efficacy are riddled with bias | Sensible Medicine

FDA's censoring rules doubled the PFS difference | Sensible Medicine - European Journal of Cancer

Oncologia

The US FDA's cancer drug approval process is broken and need audit | Sensible Medicine

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NOTÍCIAS

tabela de conteúdos ↟

Cardiovascular

 ✔ New Cardiovascular Disease Risk Calculator Could Eliminate the Need for Statins for Millions | JAMA NO

Dermatologia

✔ Antihypertensives Might Explain Some Older Adults’ New Eczema Diagnoses | JAMA NO

Geral, Geriatria & Paliativos

 ✔ Using a Virtual Scribe May Shorten EHR Time | JAMA NO

Hematologia

✗✗✗ Infected blood scandal linked to more than 3000 deaths | Lancet Haematology

Infecciologia, Microbiologia & Antimicrobianos

WHO Releases Guidance to Reduce Catheter-Associated Infections | JAMA

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✔✔✔ FOAMed

tabela de conteúdos ↟

Cardiovascular

Three Critiques of the DanGer-Shock Trial | Sensible Medicine

Continued Controversy Between Contrast and Kidneys | Journal Feed

Dermatologia

EDITOR'S PICK: Overdiagnosis and Overtreatment in Melanoma | Drug Development Letter

Doente crítico/urgente

Point | Counterpoint – Adenosine First-Line for SVT? | Journal Feed

Point | Counterpoint – Calcium Channel Blockers First-Line for SVT? | Journal Feed

Living More Days with TXA? | Journal Feed - Annals of Emergency Medicine

Geral, Geriatria & Paliativos

What’s the Best Target in the Neck for US Guided Central Access | Journal Feed

#424 Hotcakes - January 2024 | Curbsiders

Hematologia

#421 Antiphospholipid Syndrome with Dr. Arielle Langer - Curbsiders

Infecciologia, Microbiologia & Antimicrobianos

From the Doorway – How Accurate Is Physician Gestalt in Sepsis? | Journal Feed

Exploring regulatory data sets of the Comirnaty vaccine - 11b | TTE

Exploring regulatory data sets of the Comirnaty vaccine - 11c | TTE

Exploring regulatory data sets of the Comirnaty vaccine - First part | TTE

COVID19 vaccines linked to myocarditis, pericarditis, ITP, Guillain Barre, Bell's Palsy, etc | Sensible Medicine - Vaccine

Meta-investigação & MBE

Follow the narrative, not the evidence | TTE

The Importance of Proper Control Arms | John Mandrola

The Frustration of Not Being Able to Sort Signal From Noise | Sensible Medicine - Study of the Week - JAMA

For the WIN Ratio…Wait, What? | Journal Feed - AJRCC & Circulation

Oncologia

HOW TO DO A GREAT ONCOLOGY JOURNAL CLUB... LIVE EDITION! + Q&A | Drug Development Letter

Cisplatin shortage... has costs beyond loss-of-efficacy! | Drug Development Letter

Postrecurrence treatment in neo/adjuvant trials. | Sensible Medicine - JAMA Oncology

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