Junho de 2023 - Inventário do mês

TABELA DE CONTÉUDOS:

1. REVISÕES SISTEMÁTICAS DE ENSAIOS CONTROLADOS E ALEATORIZADOS (ECAs)

2. ENSAIOS CONTROLADOS E ALEATORIZADOS (ECAs)

3. NORMAS DE ORIENTAÇÃO CLÍNICA

4. OBSERVACIONAIS

   1. Revisões Sistemáticas

   2. Primários

   3. Casos clínicos e séries

5. OPINIÃO

   1. Revisões narrativas | Perspectiva | Notícias | FOAMed

Glossário:

✔✔✔ --> Muito relevante e interessante

✔ --> Relevante e interessante

(sem símbolo) --> Interessante mas pouco relevante

(sem símbolo) --> Pouco relevante e interessante

✗ --> Não relevante e pouco interessante (mas importante por contrariar hipóteses, práticas, ...)

classificação pessoal, nem todos concordarão

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REVISÕES SISTEMÁTICAS de ECAs

tabela de conteúdos ↟

Doente crítico/urgente

✔ Patient-Level Meta-Analysis of Low-Dose Hydrocortisone in Adults with Septic Shock | NEJM Evidence

Geral, Geriatria & Paliativos

✔ Moderators of the effect of therapeutic exercise for knee and hip osteoarthritis - SR&IPD-MA | Lancet Rheumatology

Imuno-mediadas

✔ Therapeutic Equivalence of Biosimilar and Reference Biologic Drugs in Rheumatoid Arthritis | JAMA Network Open

Infecciologia, Microbiologia & Antimicrobianos

✔✔✔ Evaluation of Oseltamivir Used to Prevent Hospitalization in Outpatients With Influenza | JAMA Internal Medicine

Neurologia

Cholinesterase Inhibitors for Psychotic Symptoms in Alzheimer Disease and Parkinson Disease | JAMA Neurology

Oncologia

✔ Second-generation Antiandrogens w/ Cognitive and Functional Toxic Effects in RCTs | JAMA Oncology

Changes to Primary End Points in RCTs on ICI in Urothelial, Renal Cell, and Lung Cancers | JAMA Oncology

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ENSAIOS CONTROLADOS E ALEATORIZADOS

tabela de conteúdos ↟

Cardiovascular

✔ Angiotensin-Neprilysin Inhibition in Mildly Reduced or Preserved EF and Worsening Heart Failure | JACC

✔ Self-administered IN etripamil w/ symptom-prompted, repeat-dose regimen for AVN-dependent SVT - RAPID | Lancet

GRACE risk score in admitted patients with non-ST elevation acute coronary syndrome - UKGRIS | BMJ

✗ Rivaroxaban for Postoperative Thromboprophylaxis in Patients After Bariatric Surgery | JAMA Network Open

Cirurgia, Ortopedia & MFR

Conservative management versus tonsillectomy in adults with recurrent acute tonsillitis in the UK - NATTINA | Lancet

Minithoracotomy vs Conventional Sternotomy for Mitral Valve Repair | JAMA

✗ Dexamethasone versus Surgery for Chronic Subdural Hematoma - DECSA | NEJM

Doente crítico/urgente

✔✔✔ Video versus Direct Laryngoscopy for Tracheal Intubation of Critically Ill Adults - DEVICE | NEJM

Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest - TAME | NEJM

Endocrinologia

✔✔✔ Once-Weekly Insulin Icodec vs Once-Daily Insulin Degludec in Insulin-Naive T2D - ONWARDS 2 | JAMA

✔✔✔ Weekly Icodec versus Daily Glargine U100 in Type 2 Diabetes without Previous Insulin - ONWARDS 1 | NEJM

✔✔✔ Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity | JAMA Network Open

✔✔✔ Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial | NEJM

✔ Oral Small Molecule GLP1a Danuglipron for Glycemic Control Among Type 2 Diabetes | JAMA Network Open

✗ Topical Esmolol Hydrochloride as a Novel Treatment Modality for Diabetic Foot Ulcers | JAMA Network Open

Gastroenterologia & Hepatologia

✔ Randomized placebo-controlled phase 3 trial of vibrating capsule for chronic constipation | Gastroenterology

2 Green Kiwifruits Daily Improves Constipation and Abdominal Comfort | AJG

Geral, Geriatria & Paliativos

✔ Intervention to Promote Communication About Goals of Care for Hospitalized Patients With Serious Illness | JAMA

Evaluation of Mask-Induced Cardiopulmonary Stress | JAMA NO

Hematologia

✔✔✔ Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia - PACER | NEJM

Imuno-mediadas

Avapritinib versus Placebo in Indolent Systemic Mastocytosis - PART 2 | NEJM Evidence

Infecciologia, Microbiologia & Antimicrobianos

✔ Continuous vs Intermittent Meropenem Administration in Critically Ill Patients With Sepsis - MERCY | JAMA

✔ Point-of-Care CRP to improve antibiotic targeting in respiratory illness in Vietnamese primary care | Lancet ID

Outpatient treatment of COVID-19 and incidence of post-COVID-19 condition over 10 months - COVID-OUT | LancetID

Nefrologia

✔✔✔ Effect of Hemodiafiltration or Hemodialysis on Mortality in Kidney Failure - CONVINCE | NEJM

✔✔✔ Balanced crystalloid solution versus saline in deceased donor kidney transplantation - BEST-Fluids | Lancet

Letermovir vs Valganciclovir for Prophylaxis of Cytomegalovirus in High-Risk Kidney Transplant Recipients | JAMA

Neurologia

✔✔✔ Early versus Later Anticoagulation for Stroke with Atrial Fibrillation - ELAN | NEJM

✔ Panax notoginseng Saponins in the Treatment of Adults With Ischemic Stroke in China | JAMA Network Open

✔ Butylphthalide in Patients With Acute Ischemic Stroke - BAST | JAMA Neurology

Lumbar Cerebrospinal Fluid Drain Among Aneurysmal Subarachnoid Hemorrhage - EARLYDRAIN | JAMA Neurology

ApTOLL in Patients With Ischemic Stroke Undergoing Endovascular Treatment | JAMA

Oncologia

✔ Direct Oral Anticoagulants vs Low-Molecular-Weight Heparin and Recurrent VTE in Cancer - CANVAS | JAMA

ORL

✔ Semont-Plus or Epley Maneuver in Posterior Canal Benign Paroxysmal Positional Vertigo | JAMA Neurology

Reversing Synchronized Brain Circuits Using Auditory-Somatosensory Stimulation in Tinnitus | JAMA NetOpen

Psiquiatria

✔ Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression - ELEKT-D | NEJM

Técnicas, POCUS, Exames & Outros

Ultrasonography or Radiography for Suspected Pediatric Distal Forearm Fractures - BUCKLED | NEJM

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NORMAS DE ORIENTAÇÃO CLÍNICAS - GUIDELINES

tabela de conteúdos ↟

Técnicas, POCUS, Exames & Outros

✔✔✔ Joint Advisory Statement: Emergency CT scans and IV Iodinated Contrast | RCEM-RCR

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ESTUDOS OBSERVACIONAIS

REVISÕES SISTEMÁTICAS COM ESTUDOS OBSERVACIONAIS (com ou sem ECA)

tabela de conteúdos ↟

Cardiovascular

✔ Clinical profile and outcome of isolated pulmonary embolism | Lancet Discovery Science

Doente crítico/urgente

✔✔✔ Observation, aspiration, or tube-thoracostomy for primary spontaneous pneumothorax | Chest

Geral, Geriatria & Paliativos

Dietary sugar consumption and health: umbrella review | BMJ

Infecciologia, Microbiologia & Antimicrobianos

✔ Vaginal vs Urine Swab for Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis | Ann Fam Med

PRIMÁRIOS - SUB-ANÁLISE / COORTE / CASO-CONTROLO / INQUÉRITOS / A. ECONÓMICAS

tabela de conteúdos ↟

Cardiovascular

✔✔✔ P2Y12 Inhibitor Monotherapy / Dual Antiplatelet Therapy After Complex PCI | JACC

✔✔✔ Clinical Outcomes of Intensive Inpatient Blood Pressure Management in Hospitalized Older Adults | JAMA IM

✔ Bleeding-Related Hospitalizations During Use of Amiodarone With Apixaban or Rivaroxaban in Patients w/ AF | AIM

SGLT2 Inhibitor Therapy Among Patients Hospitalized for HFrEF in the US | JAMA Cardiology

Dapagliflozin and Anemia in Patients with Chronic Kidney Disease | NEJM

Effect of Low-Dose Aspirin Versus Placebo on Incidence of Anemia in the Elderly - ASPREE post-hoc analysis | AIM

Cirurgia, Ortopedia & MFR

✔ Aspirin vs Enoxaparin on 90-Day Mortality in Patients Undergoing Hip or Knee Arthroplasty | JAMA Network Open

Association of Low-Dose Colchicine With Incidence of Knee and Hip Replacements | AIM

Diagnóstico & Raciocínio Clínico

✔✔✔ Accuracy of a Generative Artificial Intelligence Model in a Complex Diagnostic Challenge | JAMA Network Open

Automated Interpretation of Clinical Electroencephalograms Using Artificial Intelligence - SCORE-AI | JAMA Neurology

Doente crítico/urgente

✔ The SQuID Protocol (Subcutaneous Insulin in Diabetic Ketoacidosis): Impacts on ED Operational Metrics | AEM

Nurse-to-Nurse Familiarity & Mortality in the Critically Ill: Multicenter Observational Study | Am J Respir Crit Care Med

Defining successful intubation on the first attempt: laryngoscope and endotracheal tube insertions | Ann Emerg Med

Geral, Geriatria & Paliativos

✔ A national physician survey of deintensifying diabetes medications for older adults w/ type 2 diabetes | DiabetesCare

✔ Continuous palliative sedation in terminally ill patients with cancer: a Chinese palliative care unit | BMJ Open

The Volume and Cost of Quality Metric Reporting | JAMA

Content Analysis of Emoji and Emoticon Use in Clinical Texting Systems | JAMA Network Open

Hematologia

Antibiotics and Acute Graft-vs-Host Disease Following Allogeneic Hematopoietic Cell Transplantation | JAMA NO

Infecciologia, Microbiologia & Antimicrobianos

✔ Clindamycin plus Vancomycin versus Linezolid for Treatment of Necrotizing Soft Tissue Infection | OPFID

✔ Development and validation of a sulfa antibiotic allergy clinical decision rule | JAMA Network Open

✔ Medical and Mental Health Sequelae Following Hospitalization for COVID-19, Influenza, and Sepsis | JAMA IM

Clinical Characteristics and Outcomes Among Travelers With Severe Dengue | AIM

Candidemia in Cardiovascular Implantable Electronic Devices: Uncertainty in Management Based on Guidelines | IDSA

Meta-investigação & MBE

✔✔✔ Lack of Treatment Efficacy Derived From Statistically Nonsignificant Results of Randomized Clinical Trials | JAMA

✔✔✔ Prolific non-research authors in high impact scientific journals: meta-research study | Scientometrics

Neurologia

✔ Cerebrospinal fluid findings and clinical characteristics, subtype, and disease course in patients w/ GBS | Neurology

Oncologia

✔ Post-progression treatment in cancer randomized trials: trials leading to FDA approval | BMC Cancer

Técnicas, POCUS, Exames & Outros

✔✔✔ Clinically significant contrast-associated AKI after emergent CT angiography of the cerebral arteries | EJIM

CASOS CLÍNICOS e SÉRIES DE CASOS

tabela de conteúdos ↟

Cardiovascular

In-vivo Aortic Valve of a Patient with Alkaptonuria | Acta Médica Portuguesa

Imuno-mediadas

α-Gal Syndrome: A Case Report of Diagnosis and Meat Reintroduction | AIM

Infecciologia, Microbiologia & Antimicrobianos

Malignant Syphilis | NEJM

A Case of Neisseria sicca Bacteremia Due to Eculizumab Therapy | AIM

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OPINIÃO

REVISÃO NÃO-SISTEMÁTICA / NARRATIVA

tabela de conteúdos ↟

Infecciologia, Microbiologia & Antimicrobianos

Prophylaxis Against Pneumocystis jirovecii Pneumonia in Adults | JAMA

PERSPECTIVA

tabela de conteúdos ↟

Geral, Geriatria & Paliativos

✔✔✔ Update in Outpatient General Internal Medicine: Practice-Changing Evidence Published in 2022 | AJM

Infecciologia, Microbiologia & Antimicrobianos

✔ Antibiotic Myths for the Infectious Diseases Clinician | CID

✔ Ethics of antibiotic allergy | BMJ-JME

✔ Pfizer's Maternal RSV Vaccine Clears FDA Advisory Committee | Sensible Medicine

✔ Herd immunity, vaccination and moral obligation | BMJ-JME

✔ University-age vaccine mandates: reply to Lam and Nichols | BMJ-JME

✔ Public health experts went on Twitter and promoted blatant misinformation about Monkeypox | Sensible Medicine

Meta-investigação & MBE

✔✔✔ Detecting Selection Bias in Observational Studies—When Interventions Work Too Fast | JAMA Internal Medicine

✔✔✔ Promoting Ethical Integrity in Authorship Attribution: Who Can Help More? | Acta Médica Portuguesa

✔✔✔ Catalogue of bias: novelty bias | BMJ-EBM

✔ The Rapid Growth of Mega-Journals | JAMA

✔ What are science journals for, anyway? | Sensible Medicine

✔ Some Surrogate Endpoints Are Fine | Sensible Medicine

✔ Primary End Point Changes Among Active Cancer Phase 3 Randomized Clinical Trials | JAMA Network Open

✔ The Rita Redberg Era at JAMA Internal Medicine | JAMA Internal Medicine

NOTÍCIAS

tabela de conteúdos ↟

Endocrinologia

✔ Oral Semaglutide Led to Similar Weight Loss as Injection, Company Says | JAMA

WHO Warns Against Artificial Sugars for Weight Loss | JAMA

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✔✔✔ FOAMed

tabela de conteúdos ↟

Cardiovascular

#400 Antiplatelets, Anticoagulation for Coronary Artery Disease and Afib | Curbsiders

Cirurgia, Ortopedia & MFR

Appendicitis | Core IM

Doente crítico/urgente

NICE Head Injury Guidelines 2023 | St. Emlyn's

Trauma Resuscitation Updates | Rebel EM

PulmCrit: “ARDS” is not a real thing | EMCrit

JC: The PATCH trial. TXA in major trauma | St Emlyn’s

JC – Video vs Direct Laryngoscopy for Tracheal Intubation of Critically Ill Adults | St Emlyn's

Gastroenterologia & Hepatologia

# 398:Live! From SHM: Inpatient Cirrhosis Management | Curbsiders

#342 - Triglyce-Ride that High? | Tools for Practice

Geral, Geriatria & Paliativos

Managing Pain in the Elderly: Acetaminophen VS. Hydromorphone ! REBEL EM

29 May 2023 [142] Simple clinical pharmacology can improve prescribing | Therapeutics Initiative

Ep 184 Must Know Drug Interactions in Emergency Medicine | EMC

Hematologia

Thrombotic Thrombocytopenic Purpura (TTP) | Core EM

Infecciologia, Microbiologia & Antimicrobianos

Episode 71 – Slow to Resolve (Pneumonia) | Curious Clinicians

No, metformin is probably not the cure for long COVID | First10EM

Técnicas, POCUS, Exames & Outros

The CT FIRST Trial: Should We Pan-CT After ROSC? | Rebel EM

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ARA - Aumento de Risco Absoluto | EBM - Evidence-based medicine | ECA - Ensaio controlado e aleatorizado | ITT - Intention-to-treat Analysis | MA - Meta-análise | MBE - Medicina baseada na evidência | NIT - Non-inferiority trial | NNH - Number needed to harm | NNT - Number needed to treat | PPA - Per protocol analysis | RR - Redução Relativa | RRA - Redução do Risco Absoluto | RS - Revisão Sistemática