Junho 2022

Meta-Revisão

• Characteristics, quality and volume of the first 5 months of COVID-19 | BMJ EBM

• Validity of data extraction in evidence synthesis practice of AE: reproducibility study | BMJ

RS de ECA

• Cardiovascular

• Efficacy and Safety With Dose-Reduced Direct Oral Anticoagulants | JAMA Cardiology

• Adverse cardiovascular events and mortality w/ testosterone treatment |Lancet HL

• Doente crítico/urgente

• Hypothermic vs Normothermic Control after Cardiac Arrest | NEJM Evidence

• Parenteral Vitamin C in Patients with Severe Infection | NEJM Evidence

• Endocrinologia

• Sodium–Glucose Cotransporter-2 Inhibitors in Patients With Heart Failure | AIM

• Weight management interventions for adults in primary care | The BMJ

• Geral, Geriatria & Paliativos

• Opioid versus opioid-free analgesia after surgical discharge | Lancet

• eHealth-delivered exercise programmes on balance in people >65 years | BMJ Open

• Imuno-mediado

• Remote CBT and exercise for fatigue in inflammatory rheumatic diseases,LIFT|Lancet

• Infecciologia, Microbiologia & Antimicrobianos

• Chlorhexidine vs povidone and coated sutures vs uncoated in SSI | Lancet Inf Disea

• Oral Is the New IV. Challenging Decades of Blood and Bone Infection Dogma | AJM

• Meta-investigação & MBE

• Data Sharing and Reanalyses Among RCTs Published in Surgical Journals | JAMA NO

• Oncologia

• OS in Phase 3 Clinical Trials of Metastatic CRC, 1986-2016 | JAMA Network Open

• Patterns of Scientific and Clinical Impact in Cancer RCTs JAMA Network Open

• Pneumologia

• Combination fixed-dose SABA/IC in mild asthma - Cochrane Review | BMJ EBM

• Psiquiatria

• Continuing, reducing, switching or stop antipsychotics in schizophrenia | Lancet Psy

ECA

• Cardiovascular

• Unblinded and Blinded N-of-1 Trials Versus Usual Care on Statins | Circulation

• Cirurgia, Ortopedia & MFR

• Early vs Late Cardiac Rehabilitation Exercise on Poststernotomy | JAMA Cardio

• IntraOP Complete handovers of Anesthesia Cares | JAMA

• COVID-19

• Baricitinib vs dexamethasone for hospitalised COVID-19 (ACTT-4) | Lancet RespMed

• Prophylactic LMWH vs SoC in unvaccinated, at-risk outpatients (ETHIC) | Lancet H

• LMWH for prophylaxis in symptomatic outpatients with COVID-19 (OVID) | Lancet H

• Doente crítico/urgente

• Pre- and apnoeic high-flow oxygenation for RSI in the ED - Pre-AeRATE | AS

• Fluid Bolus among Critically ill intubated patients in CV collapse | JAMA Network

• Restriction of Intravenous Fluid in ICU Patients with Septic Shock | NEJM

• Diuretics vs Volume in Acute Intermediate High-Risk Pulmonary Embolism | Lung

• Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit - LOVIT | NEJM

• Gastroenterologia & Hepatologia

• Upadacitinib as induction / maintenance for moderately to severely UC | Lancet G&H

• Discontinuation of Infliximab Therapy in Crohn’s Disease | NEJM Evidence

• Geral, Geriatria & Paliativos

• Community Health Worker Among Advanced Stages of Cancer | JAMA Oncology

• Refreshing medical students’ intravenous-cannulation skillsb| BMJ Open

• Infecciologia, Microbiologia & Antimicrobianos

• Fast multiplex PCR of BAL in pneumonia at risk of Gram-neg - Flagship II | Lancet

• Short vs extended carbapenem duration in high-risk neutropenic FUO | Lancet Hem

• PETCT vs CT for persistent/recurrent neutropenic fever in high-risk (PIPPIN) |LancetH

• Nefrologia

• Periop Dexmedetomidine on Delayed Graft Function | JAMA NO

• Neurologia

• CBT for Posttraumatic Headache and PTSD Symptoms | JAMA Neurology

• Oncologia

• Supine vs Prone Breast RT on Sking AE Among Women w/ Large Breast Size | JAMA O

• Trastuzumab in Previously Treated HER2-Low Advanced Breast Cancer | NEJM

• Electronic Symptom Monitoring on PRO among Metastatic Cancer | JAMA

• Pegasparaginase-Based vs L-asparaginase–Based CT for ENKTC Lymphoma | JAMA O

• Durvalumab plus Gemcitabine/Cisplatin in Advanced Biliary Tract Cancer | NEJM Evid

• Pneumologia

• Graphic Warning Labels on Cigarette Pack–Hiding Behavior - CASA | JAMA NO

• Postdischarge Smoking Cessation Interventions - Helping HAND 4 | JAMA IM

• Varenicline Added to Counseling on Smoking Cessation Among Daily Smokers | JAMA

• Varenicline for Smoking Cessation in Type 2 Diabetes | JAMA Network Open

NORMAS DE ORIENTAÇÃO CLÍNICAS (GUIDELINES):

• COVID-19

• Awake prone positioning for non-intubated patients | Lancet Respiratory Medicine

• Infecciologia, Microbiologia & Antimicrobianos

• Treatment of AmpC β-Lactamase–Producing Gram-negative | IDSA

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RS COM ESTUDOS OBSERVACIONAIS (com ou sem ECA)

• Cardiovascular

• Decision support tool for the diagnosis of acute heart failure | The BMJ

• CAC Score Beyond Traditional Cardiovascular Risk Assessment | JAMA IM

• Meta-investigação & MBE

• Reporting Statistical Inference in Major Cancer Journals Abstracts, ‘90-’20 | JAMA NO

• Neurologia

• 2022 Guideline for the Management of Patients With sICH | AHA/ASA

• Oncologia

• Electronic Noses in Cancer Diagnoses Using Exhaled Breath | JAMA Network Open

• Pneumologia

• IPF (an Update) and PPF in Adults - ATS/ERS/JRS/ALAT | AJR & CCM

• Psiquiatria

• Intensive home treatment vs hospital admission in acute psychiatric crisis |LancetPsy

PROSPECTIVOS

• Cirurgia, Ortopedia & MFR

• Traumatic Intracranial HT - Decompressive Craniectomy vs SC at 24M | JAMA Neuro

• Hand Osteoarthritis: Two Studies | JW - AR e ACR

• Endocrinologia

• Tirzepatide Once Weekly for the Treatment of Obesity | NEJM

• Geral, Geriatria & Paliativos

• Pain, Analgesics and Satisfaction w/ Spinal vs General Anesthesia - Hip fracture | AIM

• Awareness of breast cancer overdiagnosis: a qualitative interview study | BMJ Open

• Infecciologia, Microbiologia & Antimicrobianos

• Metagenomic DNA sequencing vs urine culture | Lancet Microbe

• Quick (1h) malaria, leptospirosis, chikungunya, and dengue identification | Lancet ID

• Oncologia

• Nivolumab+cabozantinib vs sunitinib for advanced RCC - CheckMate 9ER | LancetO

• Consensus-Based Guidance on Opioids in Advanced Cancer-Related Pai | JAMA Onco

• Psiquiatria

• Emergency psychiatric (EmPATH) unit for suicidal ideation in rural America | AEM

RETROSPECTIVOS

• Cardiovascular

• Emergency vs Delayed Coronary Angiogram in Survivors of OHCA | JAMA Cardiology

• Rivaroxaban alone vs Rivaroxaban plus Antiplatelets in AF w/ CAD | JAMA Cardio

• Time-Benefit w/ Ticagrelor and Aspirin in AIS/TIA w/ CYP2C19 LoF | JAMA Neuro

• Vascular calcification on abdominal aortic aneurysm progression | JVS

• Does Hypoattenuated Leaflet Thickening After TAVR Matter? | JACC

• Longitudinal Study of COVID-19 sequelae and Immunity |Annals of Internal Medicine

• Treatment and prescribing trends of antihypertensive drugs in UK | BMJ Open

• Doente crítico/urgente

• Yield of Head CT from a 6-Year Analysis of Acute Hospital Visits | JAMA IM

• Previous Infection and Vaccination on Symptomatic Omicron Infections | NEJM

• Endocrinologia

• Gut microbe Ruminococcus gnavus and metabolic syndrome | Lancet D&E

• Practice Patterns of Fundoscopic for Diabetic Retinopathy Screening in PC | JAMA NO

• Glycemic Targets for Older Adults with Type 2 Diabetes | Diabetes Care

• Geral, Geriatria & Paliativos

• Hemorrhage Risk Among NOACs plus Tamoxifen vs Aromatase Inhibitors | JAMA NO

• Factors Associated with Physician Tolerance of Uncertainty | JGIM

• Functionality and mortality after hospitalization for extracranial hemorrhage | JHM

• Hematologia

• Molecular International Prognostic Scoring System for MDS | NEJM Evidence

• Dermatological Patients w/ Eosinophilia | Journal of Allergy and Clinical Immunology

• Infecciologia, Microbiologia & Antimicrobianos

• Human-to-human transmission of C. psittaci in China, 2020 | Lancter Microbe

• Prevalence of and factors associated with herpes zoster in England | BMC Inf Dis

• Diagnosis at Admission vs Discharge Among Possible Bacteremia | JAMA NO

• Nefrologia

• Uric Acid–Lowering Therapy and Chronic Kidney Disease | JAMA Network Open

• Pneumologia

• Phenotyping of idiopathic pulmonary arterial hypertension | Lancet P

• Electronic Cigarette and Respiratory Symptom among US Young Adults | JRCCM

• Psiquiatria

• CT for Psychiatric Presentations - 6Y Analysis of Acute Hospital Visits | JAMA IM

CASO CLÍNICO / IMAGEM CLÍNICA

• Coração e vasos - Human Response to a Porcine Heart Transplant - NEJM

• Respiratório - E-Cigarette Use, Small Airway Fibrosis, and Constrictive Bronchiolitis | NEJM

ARTIGO DE OPINIÃO

• COVID-19

• Prioritizing COVID-19 over everything: the unintended harm

• Evidence on the efficacy of ivermectin: another story of apples & oranges | BMJ EBM

• Geral, Geriatria & Paliativos

• Measuring Performance of the Diagnostic Process | Health Care Quality | JAMA

• Promoting the Values for Surrogate Decision-making | JAMA

• Meta-investigação & MBE

• Patient-reported outcome measures (PROM) as proof of treatment efficacy|BMJEBM

• Misleading clinical evidence and systematic reviews on ivermectin for COVID-19

• Increase value and reduce waste in research | BMJ Open

FOAMed

• Nefrologia

• Canadian Guidelines for CA-AKI - First10EM

• Psiquiatria

• #335 Generalized Anxiety Disorder - The Curbsiders