Setembro 2024 - Inventário do mês

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Versão esquemática de Mariana Barosa:

What multimorbidity shows us about guideline-driven evidence based medicine ou Sensible Medicine

TABELA DE CONTÉUDOS:

1. META-REVISÃO

2. REVISÕES SISTEMÁTICAS DE ENSAIOS CONTROLADOS E ALEATORIZADOS (ECAs)

3. ENSAIOS CONTROLADOS E ALEATORIZADOS (ECAs)

4. NORMAS DE ORIENTAÇÃO CLÍNICA

5. OBSERVACIONAIS

   1. Revisões Sistemáticas

   2. Primários

   3. Casos clínicos e séries

6. OPINIÃO

   1. Revisões narrativas

   2. Perspectiva

   3. Notícias

7. FOAMed

Glossário:

✔✔✔ --> Muito relevante e interessante

✔ --> Relevante e interessante

(sem símbolo) --> Interessante mas pouco relevante

(sem símbolo) --> Pouco relevante e interessante

✗ --> Não relevante e pouco interessante (mas importante por contrariar hipóteses, práticas, ...)

classificação pessoal, nem todos concordarão

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META-REVISÃO

Meta-investigação & MBE

✔✔✔ Agreement Between Mega-Trials and Smaller Trials: A Systematic Review and Meta-Research Analysis | JAMA

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REVISÕES SISTEMÁTICAS de ECAs

tabela de conteúdos ↟

Cardiovascular

✔✔✔ De-escalation to ticagrelor monotherapy vs 12 months of dual antiplatelet therapy with and without ACS | Lancet

??? Temporary mechanical circulatory support in infarct-related cardiogenic shock: IPD and 6-month follow-up | Lancet

Infecciologia, Microbiologia & Antimicrobianos

✔ Clostridioides difficile Infection Risk Following Different Antibiotics: Insights from Multi-source Medical Data | IJAA

Oncologia

✔✔✔ Randomised controlled trials on radiation dose fractionation in breast cancer | BMJ

Psiquiatria

Comparative oral monotherapy of psilocybin, LSD, MDMA, ayahuasca and escitalopram for depression | BMJ

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ENSAIOS CONTROLADOS E ALEATORIZADOS

tabela de conteúdos ↟

Cardiovascular

✔✔✔ Dapagliflozin vs. metolazone in heart failure resistant to loop diuretics | European Heart Journal

✔✔✔ Pulmonary Vein Isolation vs Sham Intervention in Symptomatic Atrial Fibrillation - SHAM-PVI | JAMA

✔✔✔ Invasive Treatment Strategy for Older Patients with Myocardial Infarction - SENIOR-RITA | NEJM

✗✗✗ Beta-Blocker Interruption or Continuation after Myocardial Infarction - ABYSS | NEJM

✔ Fasting vs no fasting prior to catheterisation laboratory procedures: the SCOFF trial | European Heart Journal

✗ Potassium Supplementation and Prevention of Atrial Fibrillation After Cardiac Surgery: The TIGHT K | JAMA

? Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction - FINEARTS | NEJM

? Transcatheter Valve Repair in Heart Failure with Moderate to Severe Mitral Regurgitation - RESHAPE-HF2 | NEJM

Edoxaban Antithrombotic Therapy for Atrial Fibrillation and Stable Coronary Artery Disease - EPIC-CAD | NEJM

Continuation vs Discontinuation of RAS Inhibitors Before Major Noncardiac Surgery - Stop-or-Not | JAMA

Endocrinologia

? Insulin Efsitora versus Degludec in Type 2 Diabetes without Previous Insulin Treatment | NEJM

Imuno-mediadas

✔ Mycophenolate Mofetil and New-Onset Systemic Lupus Erythematosus | JAMA Network Open

✔ Combinations of immunomodulatory agents for prevention of uveitis relapse in severe Behçet | Lancet Rheuma

✗ Baricitinib Withdrawal and Retreatment in Patients With Severe Alopecia Areata - BRAVE-AA1 | JAMA Dermatology

Infecciologia, Microbiologia & Antimicrobianos

✔✔✔ Topical permethrin 5% vs benzyl benzoate 25% treatment in scabies | British Journal of Dermatology

Investigating the effect of enhanced cleaning and disinfection of shared medical equipment on HCAI - CLEEN|LancetID

Tourniquet Use and Local Tissue Concentrations of Cefazolin During Total Knee Arthroplasty | JAMA Network Open

Varying Doses of Linezolid (+ Bedaquiline + Pretomanid) in Treatment of Drug-Resistant Pulmonary Tuberculosis | CID

Nefrologia

✗ Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors in Kidney Disease | NEJM Evidence

Oncologia

Transperineal vs Transrectal Prostate Biopsy—The PREVENT | JAMA Oncology

Pneumologia

✗✗✗ Long-Term Oxygen Therapy for 24 or 15 Hours per Day in Severe Hypoxemia - REDOX | NEJM

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NORMAS DE ORIENTAÇÃO CLÍNICAS - GUIDELINES

tabela de conteúdos ↟

Cardiovascular

✔ 2024 ACC on Clinical Assessment, Management, and Trajectory of Patients Hospitalized With Heart Failure | JACC

Oncologia

✔ Communication and support of patients and caregivers in chronic cancer care: ESMO Clinical Practice Guideline

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ESTUDOS OBSERVACIONAIS

REVISÕES SISTEMÁTICAS COM ESTUDOS OBSERVACIONAIS (com ou sem ECA)

Cardiovascular

✔✔✔Risk Stratification in Nonischemic Dilated Cardiomyopathy Using CMR Imaging | JAMA Cardiology

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PRIMÁRIOS - SUB-ANÁLISE / COORTE / CASO-CONTROLO / INQUÉRITOS / A. ECONÓMICAS

tabela de conteúdos ↟

Cirurgia, Ortopedia & MFR

✔ Restrictive vs usual care cholecystectomy in abdominal pain and gallstones: 5-year follow-up of SECURE | JAMA Surg

Doente crítico/urgente

Evaluation of BLS interventions for foreign body airway obstructions: A population-based cohort study | Resuscitation

Imuno-mediadas

Outdoor temperature and self-reported Raynaud's severity among people with systemic sclerosis | Lancet Rheuma

Meta-investigação & MBE

✔ FDA-approved cancer drugs reviewed through Project Orbis— harmonizing up or down? |LancetO-SensibleMedicine

Neurologia

✔ Absence of cerebrospinal fluid pleocytosis in encephalitis | Clin Infect Dis

Oncologia

✔ Time toxicity among older patients with cancer treated with palliative systemic therapy | Supportive Care in Cancer

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CASOS CLÍNICOS e SÉRIES DE CASOS

tabela de conteúdos ↟

Gastroenterologia & Hepatologia

Diagnosis of Adult IgA Vasculitis With Gastrointestinal Involvement | AIM

Hematologia

Concurrent Arterial and Venous Thromboembolism While Receiving an Aromatase Inhibitor | AIM

Imuno-mediadas

Atypical Disseminated Zoster in a Patient With Unrecognized Severe Hypogammaglobulinemia | AIM

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OPINIÃO

REVISÃO NÃO-SISTEMÁTICA / NARRATIVA

tabela de conteúdos ↟

Infecciologia, Microbiologia & Antimicrobianos

Reaction Risk to Direct Penicillin Challenges: A Systematic Review and Meta-Analysis | JAMA Internal Medicine

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PERSPECTIVA

tabela de conteúdos ↟

Infecciologia, Microbiologia & Antimicrobianos

✔✔✔ Revisiting Diagnostics: ESR and CRP: It's Time to Stop the Zombie Tests | CMI - ESCMID

Meta-investigação & MBE

✔✔✔ Guidelines Recommending That Clinicians Advise on Lifestyle Changes: Popular but Questionable Approach|AIM

✔✔✔ Stopping Trials Early for Benefit: Insights From Recent Pivotal Trials in Chronic Kidney Disease | JACC

Oncologia

✔ CDK4/6 inhibitors in early breast cancer? Uncertain benefits, guaranteed harms | EJC - Sensible Medicine

FDA "agnostic" approvals: trastuzumab deruxtecan targeting HER2 in sarcoma | Drug Development Letter - JACS

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✔✔✔ FOAMed

tabela de conteúdos ↟

Cardiovascular

Summary of trials of medical therapy after acute coronary syndrome | Cardiology Trials 

Meta-investigação & MBE

Doing statistics can be difficult but understanding them can be fairly simple | Sensible Medicine - James McCormack

Oncologia

Johns Hopkins Pancreas Cancer Screening Clinic Publishes Flawed Study | Sensible Medicine - Vinay Prasad

Is there a such thing as 'too little benefit' in oncology? | Sensible Medicine - Vinay Prasad

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