2021 - Dezembro

ECA - Ensaio clínico aleatorizado | MBE - Medicina baseada na evidência | RS - Revisão Sistemática

RS de ECA

• Endocrinologia

  • Diets for weight management in adults with type 2 diabetes | Diabetologia

  • Pharmacotherapy for adults with overweight and obesity | The Lancet

  • Intermittent Fasting: Umbrella Review of MA of RCT | JAMA Network Open

• Gastroenterologia

  • Biologics and small molecule drugs for moderate-to-severe UC, Lancet

• MBE & Meta-investigação

  • Conventional vs network MA about antibiotic prophylaxis in cancer and HSCT

  • Spin in noninferiority RCTs w/ nonsignificant results in Oncology - JAMA NO

• Neurologia

  • Ticagrelor vs Clopidogrel w/ Aspirin in Minor Ischemic Stroke and TIA

  • Device Closure of PFO After Cryptogenic stroke - JAMA NO |

• Oncologia

  • ICI in Unresectable Hepatocellular Carcinoma - JAMA NO

ECA

• Cirurgia

  • Regional vs General Anesthesia on Postop Delirium in Elderly | JAMA NO

  • Periop Patient Education via Animated Videos in H&Neck Surgery | JAMA

• COVID-19

  • NOVAVAX vaccine in North-America - NEJM

  • Ad5-nCov (recombinant adenovirus vaccine) in 18 years and older | Lancet

  • mRNA-1273 SARS-CoV-2 Vaccine in Adolescents

  • Heterologous COVID-19 vaccination (Com-COV2 NIT) - The Lancet

  • Third dose (booster) following ChAdOx1 or BNT, Lancet | ISBE

  • Immunogenicity and safety of a third dose of CoronaVac - Lancet

  • Ab 4 wks after Heterologous booster in Kidney Transplant | JAMA IM

  • REGEN-COV in high-risk outpatients

  • PEP flute self-care versus usual care in early covid-19

  • Early Remdesivir Progression Prevention to Severe Covid in Outpat | NEJM

  • Molnupiravir in Nonvaccinated Nonhospitalized Patients | NEJM

  • Convalescent Plasma on Disease Progression

  • nAB for Hospitalized Patients According to Baseline Ag Levels | AIM

  • Two nAB, sotrovimab and BRII-196 plus BRII-198 (TICO) - The Lancet

  • Lenzilumab in hospitalised COVID-19 pneumonia (LIVE-AIR) | Editorial

  • Namilumab or infliximab vs SoC, proof of concept (CATALYST) - The Lancet

  • High-Flow Oxygen Therapy vs COT on IMV and Recovery in Severe COVID

  • Rivaroxaban for post-discharge thromboprophylaxis (MICHELLE) - Lancet

• Doente crítico

  • Diagnostic Strategy in suspected PE - YEARS + D-Dimer vs D-dimer

  • Bougie vs Stylet on First Attempt Intubation - JAMA NO | First10EM

  • Multiorgan Focused Clinical US in Cardiopulmonary diagnosis | JAMA NO

• Gastroenterologia

  • Hemostatic Powder in the treatment of Upper Nonvariceal Lesions - AIM

  • FMT after ABT for UC (LOTUS) - The Lancet

  • Intensive therapy vs standard for symptomatic intestinal CD - Lancet spin !

• Geral

  • Algorithm to Stop Night Checks for Reducing Sleep Interruption | JAMA IM

• Geriatria & Paliativos

  • Digital Health–Based Self-management Program in CD | JAMA NO

• Hematologia

• Imuno-mediado

  • Tapinarof Cream for Plaque Psoriasis

  • Ianalumab (VAY736) in primary Sjögren's syndrome - Lancet

  • TDM vs ST During Infliximab on Immune-Mediated Diseases | JAMA NO

  • Spesolimab (anti-IL36) for Generalized Pustular Psoriasis | NEJM

• Infecciologia, Microbiologia & Antibióticos

  • Ivermectin and dihydroartemisinin–piperaquine against malaria | Lancet

  • Multicomponent Strategies of Tuberculosis Testing | NEJM

• Neurologia

  • Omega-3 FA on Risk of Depression | JAMA Network

  • DRI (COMT or MAO-B inhib) vs DA in uncontrolled PD w/ Levodopa | JAMA

• Oncologia

  • PORT vs no-PORT in completely resected NSCLC N2 (Lung ART) - Lancet

  • Nivolumab vs sorafenib in advanced hepatocellular carcinoma - The Lancet

  • GnRHa in Premenopausal Women in Chemotherapy | JAMA Oncology

  • Telephone based management of AE during CT for early stage breast cancer

  • KdD vs Kd against relapsed or refractory multiple myeloma (CANDOR)

  • Polatuzumab Vedotin in Previously Untreated DLBCL - NEJM

  • Second-Line Tisagenlecleucel or SC in Aggressive B-Cell Lymphoma - NEJM

  • Axicabtagene Ciloleucel as Second-Line Therapy for LBCL - NEJM

• Ortopedia & MFR

  • Multifactorial falls prevention programme in older people - Cluster RCT

• Pneumologia

  • Financial incentives for smoking cessation in pregnancy

  • Elexacaftor plus tezacaftor/ivacaftor vs tezacaftor/ivacaftor in CF | Lancet

• Psiquiatria

  • Pimavanserin for negative symptoms of schizophrenia

  • Ketamin vs. Midazolam for PTSD | AJP

GUIDELINES

• COVID-19

  • A living WHO guideline on drugs for covid-19 - 7th version

• Geriatria & Paliativos

  • Evaluation of guideline on Fall Prevention/Management for Older - JAMA NO

REVISÃO DE OBSERVACIONAIS (com ou sem ECA’s)

• COVID-19

  • Neutralising antibody titres as predictors of protection against SARS-CoV-2

  • Update Alert 3: Ventilation Techniques and COVID-19 | AIM

  • Asymptomatic SARS-CoV-2 Infections | JAMA Network Open

• Doente Crítico

  • Safety and Efficiency of Diagnostic Strategies for Ruling Out PE | AIM

• Endocrinologia

  • Oral octreotide vs injectable SS receptor ligands in acromegaly - The Lancet

• MBE & Meta-investigação

  • Trustworthiness of Guidelines for COVID-19 treatment - JAMA NO

  • Industry involvement in rheumatology recommendations - Lancet Rheuma

• Oncologia

  • Anticancer Drugs Approved by the FDA According to Their MoA - JAMA NO

PROSPECTIVOS

• Cardiovascular

  • Apo B, Lipoproteins and risk of MI - JAMA Cardiology | JW

  • Statin Discontinuation and Cardiovascular Events Among Older People

  • Finerenone Reduces HF in DKD (FIGARO), Circulation | JW

  • Variability in Reassessment of LVEF After Myocardial Infarction

  • Mobile Health–Technology pathway on AF in Multimorbidity | JAMA Network

• Cirurgia

  • 3D-CAM for Identification of post-OP Delirium in Older | JAMA Network Open

• COVID-19

  • T-cell and Ab after first BNT162b2 vaccine dose in previously infected

  • CoronaVac and seropositivity in autoimmune RD - Lancet Rheumatology

  • Hybrid immunity vs vaccine-induced immunity in rheumatic diseases

  • Viral characteristics between alpha and delta / vaccinated and unvaccinated

  • Humoral Response to BNT162b2 Covid-19 Vaccine over 6 Months

  • Ab Response and Breakthrough Infection in Patients w/ Dialysis | AIM

  • Ab Titers Before and After a Third Dose of BNT162b2 Vaccine in Older Adults

  • BNT162b2 mRNA booster in actively treated patients w/ cancer - Lancet

  • Humoral and cellular immune responses to 2 / 3 doses in rituximab-treated patients with rheumatoid arthritis - The Lancet Rheumatology

  • COVID-19 Vaccine Type and AEs Following Vaccination | JAMA Network

  • SARS-CoV-2 antigen-detecting rapid tests for the delta and other variants

  • Assessment of Preferences for Telehealth in Post–COVID-19 Health Care

• Geriatria & Paliativos

  • Preferences for Novel Care Modalities in Chronic Illness | JAMA NO

• Imagiologia

  • AI–Based Chest X-ray Model on Human Nodule Detection | JAMA NO

• MBE & Meta-investigação

  • Factors for Systematic Evidence Assessments in Clinical Trials

• Nefrologia

  • Timing of dialysis initiation to reduce mortality and cardiovascular events

• Neurologia

  • Twenty-Year Change in Outcome of Ischemic and Hemorrhagic Strokes - report bias

  • Endovascular Therapy in Acute Basilar Artery Occlusion | JAMA NO

• Oncologia

  • USPSTF2013 vs PLCOm2012 for lung cancer screening - The Lancet

• Pneumologia

  • e-Cigarette Among Smokers without Planning to Quit intention | JAMA NO

RETROSPECTIVOS

• Cardiovascular

  • Prescribing of Statins After Lower Extremity Revascularization

  • Inclusion of Smoking Data in ASCVD Risk Calculator - JAMA Cardiology

  • Empagliflozin and background therapies, EMPEROR-Reduced post-hoc

  • Dapagliflozin and DM2 prevention, DAPA-HF & DAPA-CKD post-hoc

  • Rivaroxaban vs Apixaban in Adverse Events in AF | JAMA NO

• Cirurgia

  • Factors Relevant to Patients in Pain Control After Surgery - JAMA Network

• COVID-19

  • Severity of Delta vs Beta Variant in Qatar | JAMA Internal Medicine

  • Omicron in South Africa - admissions and vaccine effectiveness | NEJM

  • Reduced neutralisation of SARS-CoV-2 omicron - The Lancet

  • Outcomes in South Africa during Omicron Wave vs. Other Waves | JAMA NO

  • Moderna vs. Pfizer in 24-weeks outcomes and alpha vs. delta

  • Moderna, Pfizer and Janssen effectiveness against delta with time

  • Natural Immunity against reinfection with Alpha and Beta Variants

  • Immunogenicity of Extended mRNA SARS-CoV-2 Vaccine Dosing Intervals

  • Immunity after the BNT162b2 Vaccine in Israel

  • BNT162b2 Vaccine Protection against SARS-CoV-2 Infection

  • Effectiveness of mRNA Vaccine Against Infection in Older Male | JAMA NO

  • mRNA Vaccination Effectiveness Against Infection or Death in Elderly | AIM

  • Vaccine Effectiveness and Delta/VoC in Utah | JAMA NO

  • Two-dose ChAdOx1 nCoV-19 protection over time | The Lancet

  • BNT162b2 Booster and Mortality Due to Covid-19 in Israel | NEJM

  • BNT162b2 Booster in Long-term Care Facilities in Israel | NEJM

  • Protection of BNT162b2 Booster across Age Groups in Israel | NEJM

  • Third BNT162b2 Vaccination Neutralization of beta, delta and omicron | NEJM

  • Testing Among Residential College Students in Connecticut | JAMA NO

  • Invasive pneumococcal disease after three COVID-19 waves in England

  • Myocarditis after Pfizer Vaccine in a Large Healthcare Organization (Israel)

  • VITT after 1st Dose and 2nd Dose | NEJM

• Doente crítico

  • Thiamine Supplementation in Patients w/ Critical ilness and AUD - AIM

• Endocrinologia

  • Statin Therapy Initiation and Diabetes Progression /JWatch

• Gastroenterologia

  • CCR incidence, mortality, tumour characteristics, and treatment after FIT

  • APCAb and Gastric Cancer Risk in non-Hp women | JAMA Oncology

• Hematologia

  • Recurrent VTE and Bleeding With Apixaban vs Rivaroxaban - AIM

• Imuno-mediado

  • Mortality (All-cause, CVD & Cancer) in Bullous Pemphigoid | JAMA NO

• Infecciologia, Microbiologia & Antibióticos

• MBE & Meta-investigação

  • Low-Value Services Identified in US Choosing Wisely Recommendations

  • Financial Associations of Editorials and Sponsors on CV Intervention Trials

  • ML Algorithms for Predicting Progression to Dementia | JAMA Network Open

  • Comparison of Routinely Collected Data vs Clinical Adjudication | JAMA NO

• Nefrologia

  • Patient-Specific Kidney Transplant Function w/ Deep Learning | JAMA NO

• Neurologia

  • Thrombectomy for a low ASPECTS in early and extended window - JAMA NO

  • Antiseizure Drug and Mortality for Poststroke Epilepsy - JAMA Neurology - Spin Bias

  • Systolic BP and Dementia Risk with Age (U-shaped curve) - JAMA IM

• Oncologia

  • CE vs US Imaging in diagnosing LN Metastasis in H&N CSCC | JAMA

  • 2nd Generation Antiandrogens and Depression | JAMA Network Open

• Ortopedia & MFR

  • Steroid Injections for Hip Osteoarthritis — Not Necessarily Benign

• Pneumologia

  • Cardiovascular Safety for Smoking Cessation Pharmacotherapies in Australia

• Psiquiatria

CASO CLÍNICO

• ECG

  • Two Wrongs Do Not Always Make a Right

  • Brugada pattern vs. Brugada syndrome - Differential Diagnosis

  • WCT w/ Unexpected Break in the Negative QRS Concordance

  • R-on-T phenomen After Diarrhea and Syncope in the Emergency Department

  • Evolution of de Winter Into Wellens on Electrocardiogram

  • An Unusual Cause of Complete AVB in a Patient With Pedal Swelling

  • Transient ST-Segment Elevation and QTc Interval Prolongation

  • An Underrecognized Cause of Diffuse T-Wave Inversion

• Músculo-esquelético - Severe Polyarthralgia After Kidney Transplant

ANÁLISE ECONÓMICA / CUSTO-EFECTIVIDADE / CUSTO-UTILIDADE

• Cardiovascular

  • Cost-effectiveness of Cardiac Telerehabilitation w/ Relapse Prevention - CAD

• Oncologia

  • Spending on 10 Accelerated Approved Drugs Lacking Clinical Benefit

  • CE 2021 vs 2013 USPSTF on Lung Cancer Screening - JAMA Oncology

OUTROS

• Cardiovascular

  • Should practice change to antiHT bedtime administration? - BMJ EBM

  • Consider a CT angiogram before angiogram in NSTEMI - BMJ EBM

  • Alcohol and atrial fibrillation: to or not to drink? - BMJ EBM

• COVID-19

  • COVID-19 Vaccine Makers Plan for Annual Boosters, but It's Not Clear They'll Be Needed

  • Bureaucracy has created a mess for Novavax volunteers like me

  • Covid-19: Antibody boost after third dose varies greatly by COV-BOOST

  • Omicron variant and booster COVID-19 vaccines - The Lancet

  • Vaccine strategies must focus on severe disease and global equity - Lancet

  • Risk Heterogeneity and the Illusion of Waning Vaccine Efficacy | AIM

• Doente crítico

  • Epinephrine in the treatment of out-of-hospital cardiac arrest - BMJ EBM

• Gastroenterologia

  • No role for TXA in the treatment of acute GI bleeding - BMJ EBM

  • Small intestine-release peppermint oil is beneficial in IBS - BMJ EBM

• Geral

  • Preventing readmissions through better medication continuity - BMJ EBM

• Less is more (JAMA)

  • Preoperative Stress Testing Before Elective Arthroplasty

  • Closing the Osteoporosis Care Gap

  • Reconsidering Reliance on Positive Urine Drug Screen Results

  • The Next Frontier of Less Is More

  • To Restrain or Not to Restrain

• MBE & Meta-investigação

  • Optimising the process of conducting a scoping review - BMJ-EBM

  • Delays in publishing SR registrations in PROSPERO - BMJ EBM

• Neurologia

  • Thrombolysis w/ tPA 3-4.5h after AIS: trial reanalysis - BMJ EBM

• Ortopedia & MFR

  • Virtual Reality Device Is Authorized to Relieve Back Pain | JAMA Network

• Oncologia

  • Early salvage vs adjuvant therapy following prostatectomy - BMJ EBM

• Pneumologia

  • RSV Vaccines Could Prevent Tens of Thousands of Yearly Deaths | JAMA

• POCUS

  • The Cardiac Arrest Sonographic Assessment (CASA) exam – POCUS in PEA

  • POCUS — Visually Satisfying Medicine or Evidence-Based Medicine?

FOAMed

• Cardiovascular

  • #310 No Tension About Inpatient HT - Dr. Noble Maleque, The Curbsiders

  • Posterior OMIs and STDmaxV1-4 - REBEL EM

  • Mandrola's Top 10 Cardiology Stories of 2021

  • A deep dive into sglt2i - TI

• COVID-19

  • The CCEDRRN COVID-19 Infection Score (CCIS) Infographic - CanadiEM

  • COV-BARRIER: Baricitinib in ECMO/MV Patients - REBEL EM

• Doente crítico

  • Are You Pausing Too Long During CPR?

  • JC: Can we use smaller pigtail drains in traumatic haemothorax? • St Emlyn's

  • Meta-Analysis on Topical TXA for Epistaxis - REBEL EM

  • What is the Role of Contrast in Abdominal CT in the ED? - CanadiEM

  • Troubleshooting the Vent - REBEL EM

• Geral

  • Best Evidence: VTE prophylaxis in medical patients: is it worth it? - TI

  • #313 Recap Extravaganza 2021 - The Curbsiders

  • Best Articles of 2021 — JournalFeed

• Infecciologia, Microbiologia & Antibióticos

  • Evidence-Based Approach to Outpatient CAP - TI

• Nefrologia

  • The 2021 KDIGO GN Guidelines — NephJC

  • LUST but do not fall in Love with POCUS yet? — NephJC

• Neurologia

  • Optimal management strategies for primary headache in the ED - CanadiEM

  • Thrombolysis + Thrombectomy for LVO Acute Ischemic Stroke | REBEL EM